ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [cache]
453) As found in native tissue, Lgr5 and Tert expressing cells resolved into two discreet populations, which were stable over time.
--- ABSTRACT ---
PMID:24115167 DOI:10.1002/mc.22089
2015 Molecular carcinogenesis
* Development of intestinal organoids as tissue surrogates: cell composition and the epigenetic control of differentiation.
- Intestinal organoids are multicellular crypt-like structures that can be derived from adult intestinal stem cells (ISCs), embryonic stem cells (ESCs) or induced pluripotent stem cells (IPSCs). Here we show that intestinal organoids generated from mouse ESCs were enriched in ISCs and early progenitors. Treatment of these organoids with a γ-secretase inhibitor increased Math1 and decreased Hes1 expression, indicating Notch signaling regulates ISC differentiation in these organoids. Lgr5 and Tert positive ISCs constituted approximately 10% and 20% of the organoids. As found in native tissue, Lgr5 and Tert expressing cells resolved into two discreet populations, which were stable over time. Intestinal organoids derived from cancer-prone Apc(Min/+) mice showed similar numbers of ISCs, but had reduced Math1 expression, indicating a suppressed secretory cell differentiation potential (as found in intestinal tissue). Apc(Min/+) organoids were used to screen epigenetically active compounds for those that increased Math1 expression and organoid differentiation (including HDAC inhibitors, Sirtuin (SIRT) modulators and methyltransferase inhibitors). Broad-spectrum HDAC inhibitors increased both Math1 and Muc2 expression, indicating an ability to promote the suppressed secretory cell differentiation pathway. Other epigenetic compounds had a diverse impact on cell differentiation, with a strong negative correlation between those that activated the secretory marker Muc2 and those that activated the absorptive cell marker Fabp2. These data show that ESC-derived intestinal organoids can be derived in large numbers, contain distinct ISC types and can be used to screen for agents that promote cell differentiation through different lineage pathways.
--- ABSTRACT END ---
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(1)143 was (6)22 been (11)6 are (16)3 that
(2)110 were (7)12 and (12)5 be (17)2 analysis
(3)46 We (8)10 is (13)5 those (18)2 as
(4)29 we (9)10 not (14)3 authors (19)2 examination
(5)25 also (10)10 study (15)3 have

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--- WordNet output for found --- =>設立する, 基礎づける Overview of noun found The noun found has 1 sense (first 1 from tagged texts) 1. (1) found -- (food and lodging provided in addition to money; "they worked for $30 and found") Overview of verb found The verb found has 3 senses (first 2 from tagged texts) 1. (9) establish, set up, found, launch -- (set up or found; "She set up a literacy program") 2. (4) establish, found, plant, constitute, institute -- (set up or lay the groundwork for; "establish a new department") 3. establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") Overview of verb find The verb find has 16 senses (first 13 from tagged texts) 1. (159) find, happen, chance, bump, encounter -- (come upon, as if by accident; meet with; "We find this idea in Plato"; "I happened upon the most wonderful bakery not very far from here"; "She chanced upon an interesting book in the bookstore the other day") 2. (141) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 3. (86) find, regain -- (come upon after searching; find the location of something that was missed or lost; "Did you find your glasses?"; "I cannot find my gloves!") 4. (57) determine, find, find out, ascertain -- (establish after a calculation, investigation, experiment, survey, or study; "find the product of two numbers"; "The physicist who found the elusive particle won the Nobel Prize") 5. (57) find, feel -- (come to believe on the basis of emotion, intuitions, or indefinite grounds; "I feel that he doesn't like me"; "I find him to be obnoxious"; "I found the movie rather entertaining") 6. (45) witness, find, see -- (perceive or be contemporaneous with; "We found Republicans winning the offices"; "You'll see a lot of cheating in this school"; "The 1960's saw the rebellion of the younger generation against established traditions"; "I want to see results") 7. (41) line up, get hold, come up, find -- (get something or somebody for a specific purpose; "I found this gadget that will serve as a bottle opener"; "I got hold of these tools to fix our plumbing"; "The chairman got hold of a secretary on Friday night to type the urgent letter") 8. (34) discover, find -- (make a discovery, make a new finding; "Roentgen discovered X-rays"; "Physicists believe they found a new elementary particle") 9. (29) discover, find -- (make a discovery; "She found that he had lied to her"; "The story is false, so far as I can discover") 10. (16) find -- (obtain through effort or management; "She found the time and energy to take care of her aging parents"; "We found the money to send our sons to college") 11. (16) rule, find -- (decide on and make a declaration about; "find someone guilty") 12. (13) receive, get, find, obtain, incur -- (receive a specified treatment (abstract); "These aspects of civilization do not find expression or receive an interpretation"; "His movie received a good review"; "I got nothing but trouble for my good intentions") 13. (11) find -- (perceive oneself to be in a certain condition or place; "I found myself in a difficult situation"; "When he woke up, he found himself in a hospital room") 14. recover, retrieve, find, regain -- (get or find back; recover the use of; "She regained control of herself"; "She found her voice and replied quickly") 15. find -- (succeed in reaching; arrive at; "The arrow found its mark") 16. find oneself, find -- (accept and make use of one's personality, abilities, and situation; "My son went to Berkeley to find himself") Overview of adj found The adj found has 1 sense (first 1 from tagged texts) 1. (1) found -- (come upon unexpectedly or after searching; "found art"; "the lost-and-found department") --- WordNet end ---