ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [no cache] 500 found
300) In full agreement with those published results, we found a reduction of current amplitude by ~20% after depletion of PI(4,5)P 2 and a small left shift in the activation curve of KV 1.2 channels.
--- ABSTRACT ---
PMID:23907203 DOI:10.4161/chan.25816
2015 Channels (Austin, Tex.)
* The phosphoinositide sensitivity of the K(v) channel family.
- Recently, we screened several KV channels for possible dependence on plasma membrane phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2). The channels were expressed in tsA-201 cells and the PI(4,5)P 2 was depleted by several manipulations in whole-cell experiments with parallel measurements of channel activity. In contrast to reports on excised-patches using Xenopus laevis oocytes, we found only KV 7, but none of the other tested KV channels, to be strongly dependent on PI(4,5)P 2. We now have extended our study to KV 1.2 channels, a KV channel we had not previously tested, because a new published study on excised patches showed regulation of the voltage-dependence of activation by PI(4,5)P 2. In full agreement with those published results, we found a reduction of current amplitude by ~20% after depletion of PI(4,5)P 2 and a small left shift in the activation curve of KV 1.2 channels. We also found a small reduction of KV 11.1 (hERG) currents that was not accompanied by a gating shift. In conclusion, our whole-cell methods yield a PI(4,5)P 2-dependence of KV 1.2 currents in tsA-201 cells that is comparable to findings from excised patches of Xenopus laevis oocytes. We discuss possible physiological rationales for PI(4,5)P 2 sensitivity of some ion channels and insensitivity of others.
--- ABSTRACT END ---
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(1)143 was (6)22 been (11)6 are (16)3 that
(2)110 were (7)12 and (12)5 be (17)2 analysis
(3)46 We (8)10 is (13)5 those (18)2 as
(4)29 we (9)10 not (14)3 authors (19)2 examination
(5)25 also (10)10 study (15)3 have

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--- WordNet output for found --- =>設立する, 基礎づける Overview of noun found The noun found has 1 sense (first 1 from tagged texts) 1. (1) found -- (food and lodging provided in addition to money; "they worked for $30 and found") Overview of verb found The verb found has 3 senses (first 2 from tagged texts) 1. (9) establish, set up, found, launch -- (set up or found; "She set up a literacy program") 2. (4) establish, found, plant, constitute, institute -- (set up or lay the groundwork for; "establish a new department") 3. establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") Overview of verb find The verb find has 16 senses (first 13 from tagged texts) 1. (159) find, happen, chance, bump, encounter -- (come upon, as if by accident; meet with; "We find this idea in Plato"; "I happened upon the most wonderful bakery not very far from here"; "She chanced upon an interesting book in the bookstore the other day") 2. (141) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 3. (86) find, regain -- (come upon after searching; find the location of something that was missed or lost; "Did you find your glasses?"; "I cannot find my gloves!") 4. (57) determine, find, find out, ascertain -- (establish after a calculation, investigation, experiment, survey, or study; "find the product of two numbers"; "The physicist who found the elusive particle won the Nobel Prize") 5. (57) find, feel -- (come to believe on the basis of emotion, intuitions, or indefinite grounds; "I feel that he doesn't like me"; "I find him to be obnoxious"; "I found the movie rather entertaining") 6. (45) witness, find, see -- (perceive or be contemporaneous with; "We found Republicans winning the offices"; "You'll see a lot of cheating in this school"; "The 1960's saw the rebellion of the younger generation against established traditions"; "I want to see results") 7. (41) line up, get hold, come up, find -- (get something or somebody for a specific purpose; "I found this gadget that will serve as a bottle opener"; "I got hold of these tools to fix our plumbing"; "The chairman got hold of a secretary on Friday night to type the urgent letter") 8. (34) discover, find -- (make a discovery, make a new finding; "Roentgen discovered X-rays"; "Physicists believe they found a new elementary particle") 9. (29) discover, find -- (make a discovery; "She found that he had lied to her"; "The story is false, so far as I can discover") 10. (16) find -- (obtain through effort or management; "She found the time and energy to take care of her aging parents"; "We found the money to send our sons to college") 11. (16) rule, find -- (decide on and make a declaration about; "find someone guilty") 12. (13) receive, get, find, obtain, incur -- (receive a specified treatment (abstract); "These aspects of civilization do not find expression or receive an interpretation"; "His movie received a good review"; "I got nothing but trouble for my good intentions") 13. (11) find -- (perceive oneself to be in a certain condition or place; "I found myself in a difficult situation"; "When he woke up, he found himself in a hospital room") 14. recover, retrieve, find, regain -- (get or find back; recover the use of; "She regained control of herself"; "She found her voice and replied quickly") 15. find -- (succeed in reaching; arrive at; "The arrow found its mark") 16. find oneself, find -- (accept and make use of one's personality, abilities, and situation; "My son went to Berkeley to find himself") Overview of adj found The adj found has 1 sense (first 1 from tagged texts) 1. (1) found -- (come upon unexpectedly or after searching; "found art"; "the lost-and-found department") --- WordNet end ---