ELIZA

return kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [no cache] 500 found

278) We found that although all MSCs were phenotypically similar to each other, Wharton's jelly (WJ) MSCs and dental pulp stem cells (DPSCs) were highly proliferative as compared to bone marrow (BM) MSCs and adipose tissue (AD) MSCs.

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PMID:23229816 DOI:10.1002/term.1663

2015 Journal of tissue engineering and regenerative medicine

* Unique molecular signatures influencing the biological function and fate of post-natal stem cells isolated from different sources.

- The discovery of mesenchymal stem cells (MSCs) from a myriad of tissues has triggered the initiative of establishing tailor-made stem cells for disease-specific therapy. Nevertheless, lack of understanding on the inherent differential propensities of these cells may restrict their clinical outcome. Therefore, a comprehensive study was done to compare the proliferation, differentiation, expression of cell surface markers and gene profiling of stem cells isolated from different sources, viz. bone marrow, Wharton's jelly, adipose tissue and dental pulp. We found that although all MSCs were phenotypically similar to each other, Wharton's jelly (WJ) MSCs and dental pulp stem cells (DPSCs) were highly proliferative as compared to bone marrow (BM) MSCs and adipose tissue (AD) MSCs. Moreover, indistinguishable cell surface characteristics and differentiation capacity were confirmed to be similar among all cell types. Based on gene expression profiling, we postulate that BM-MSCs constitutively expressed genes related to inflammation and immunodulation, whereas genes implicated in tissue development were highly expressed in AD-MSCs. Furthermore, the transcriptome profiling of WJ-MSCs and DPSCs revealed an inherent bias towards the neuro-ectoderm lineage. Based on our findings, we believe that there is no unique master mesenchymal stem cell that is appropriate to treat all target diseases. More precisely, MSCs from different sources exhibit distinct and unique gene expression signatures that make them competent to give rise to specific lineages rather than others. Therefore, stem cells should be subjected to rigorous characterization and utmost vigilance needs to be adopted in order to choose the best cellular source for a particular disease.

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[frequency of prior(left) word to found]

(1)143 was	(6)22 been	(11)6 are	(16)3 that
(2)110 were	(7)12 and	(12)5 be	(17)2 analysis
(3)46 We	(8)10 is	(13)5 those	(18)2 as
(4)29 we	(9)10 not	(14)3 authors	(19)2 examination
(5)25 also	(10)10 study	(15)3 have

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--- WordNet output for found --- =>設立する, 基礎づける Overview of noun found The noun found has 1 sense (first 1 from tagged texts) 1. (1) found -- (food and lodging provided in addition to money; "they worked for $30 and found") Overview of verb found The verb found has 3 senses (first 2 from tagged texts) 1. (9) establish, set up, found, launch -- (set up or found; "She set up a literacy program") 2. (4) establish, found, plant, constitute, institute -- (set up or lay the groundwork for; "establish a new department") 3. establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") Overview of verb find The verb find has 16 senses (first 13 from tagged texts) 1. (159) find, happen, chance, bump, encounter -- (come upon, as if by accident; meet with; "We find this idea in Plato"; "I happened upon the most wonderful bakery not very far from here"; "She chanced upon an interesting book in the bookstore the other day") 2. (141) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 3. (86) find, regain -- (come upon after searching; find the location of something that was missed or lost; "Did you find your glasses?"; "I cannot find my gloves!") 4. (57) determine, find, find out, ascertain -- (establish after a calculation, investigation, experiment, survey, or study; "find the product of two numbers"; "The physicist who found the elusive particle won the Nobel Prize") 5. (57) find, feel -- (come to believe on the basis of emotion, intuitions, or indefinite grounds; "I feel that he doesn't like me"; "I find him to be obnoxious"; "I found the movie rather entertaining") 6. (45) witness, find, see -- (perceive or be contemporaneous with; "We found Republicans winning the offices"; "You'll see a lot of cheating in this school"; "The 1960's saw the rebellion of the younger generation against established traditions"; "I want to see results") 7. (41) line up, get hold, come up, find -- (get something or somebody for a specific purpose; "I found this gadget that will serve as a bottle opener"; "I got hold of these tools to fix our plumbing"; "The chairman got hold of a secretary on Friday night to type the urgent letter") 8. (34) discover, find -- (make a discovery, make a new finding; "Roentgen discovered X-rays"; "Physicists believe they found a new elementary particle") 9. (29) discover, find -- (make a discovery; "She found that he had lied to her"; "The story is false, so far as I can discover") 10. (16) find -- (obtain through effort or management; "She found the time and energy to take care of her aging parents"; "We found the money to send our sons to college") 11. (16) rule, find -- (decide on and make a declaration about; "find someone guilty") 12. (13) receive, get, find, obtain, incur -- (receive a specified treatment (abstract); "These aspects of civilization do not find expression or receive an interpretation"; "His movie received a good review"; "I got nothing but trouble for my good intentions") 13. (11) find -- (perceive oneself to be in a certain condition or place; "I found myself in a difficult situation"; "When he woke up, he found himself in a hospital room") 14. recover, retrieve, find, regain -- (get or find back; recover the use of; "She regained control of herself"; "She found her voice and replied quickly") 15. find -- (succeed in reaching; arrive at; "The arrow found its mark") 16. find oneself, find -- (accept and make use of one's personality, abilities, and situation; "My son went to Berkeley to find himself") Overview of adj found The adj found has 1 sense (first 1 from tagged texts) 1. (1) found -- (come upon unexpectedly or after searching; "found art"; "the lost-and-found department") --- WordNet end ---