ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [no cache] 500 found
273) We found that Pb(2+) induces gastrin hormone gene transcription and translation in a time-dependent manner.
--- ABSTRACT ---
PMID:23765435 DOI:10.1002/tox.21878
2015 Environmental toxicology
* Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells.
- Divalent lead ions (Pb(2+) ) are toxic environmental pollutants known to cause serious health problems in humans and animals. Absorption of Pb(2+) from air, water, and food takes place in the respiratory and digestive tracts. The ways in which absorbed Pb(2+) affects cell physiology are just beginning to be understood at the molecular level. Here, we used reverse transcription PCR and Western blotting to analyze cultures of human gastric carcinoma cells exposed to 10 μM lead nitrate. We found that Pb(2+) induces gastrin hormone gene transcription and translation in a time-dependent manner. Promoter deletion analysis revealed that activator protein 1 (AP1) was necessary for gastrin gene transcription in cells exposed to Pb(2+) . MitogIen-activated protein kinase (MAPK)/ERK kinase inhibitor PD98059 suppressed the Pb(2+) -induced increase in messenger RNA. Epidermal growth factor receptor (EGFR) inhibitors AG1478 and PD153035 reduced both transcription and phosphorylation by extracellular signal-regulated kinase (ERK1/2). Cells exposed to Pb(2+) also increased production of c-Jun protein, a component of AP1, and over-expression of c-Jun enhanced activation of the gastrin promoter. In sum, the findings suggest the EGFR-ERK1/2-AP1 pathway mediates the effects of Pb(2+) on gastrin gene activity in cell culture.
--- ABSTRACT END ---
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(1)143 was (6)22 been (11)6 are (16)3 that
(2)110 were (7)12 and (12)5 be (17)2 analysis
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(4)29 we (9)10 not (14)3 authors (19)2 examination
(5)25 also (10)10 study (15)3 have

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--- WordNet output for found --- =>設立する, 基礎づける Overview of noun found The noun found has 1 sense (first 1 from tagged texts) 1. (1) found -- (food and lodging provided in addition to money; "they worked for $30 and found") Overview of verb found The verb found has 3 senses (first 2 from tagged texts) 1. (9) establish, set up, found, launch -- (set up or found; "She set up a literacy program") 2. (4) establish, found, plant, constitute, institute -- (set up or lay the groundwork for; "establish a new department") 3. establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") Overview of verb find The verb find has 16 senses (first 13 from tagged texts) 1. (159) find, happen, chance, bump, encounter -- (come upon, as if by accident; meet with; "We find this idea in Plato"; "I happened upon the most wonderful bakery not very far from here"; "She chanced upon an interesting book in the bookstore the other day") 2. (141) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 3. (86) find, regain -- (come upon after searching; find the location of something that was missed or lost; "Did you find your glasses?"; "I cannot find my gloves!") 4. (57) determine, find, find out, ascertain -- (establish after a calculation, investigation, experiment, survey, or study; "find the product of two numbers"; "The physicist who found the elusive particle won the Nobel Prize") 5. (57) find, feel -- (come to believe on the basis of emotion, intuitions, or indefinite grounds; "I feel that he doesn't like me"; "I find him to be obnoxious"; "I found the movie rather entertaining") 6. (45) witness, find, see -- (perceive or be contemporaneous with; "We found Republicans winning the offices"; "You'll see a lot of cheating in this school"; "The 1960's saw the rebellion of the younger generation against established traditions"; "I want to see results") 7. (41) line up, get hold, come up, find -- (get something or somebody for a specific purpose; "I found this gadget that will serve as a bottle opener"; "I got hold of these tools to fix our plumbing"; "The chairman got hold of a secretary on Friday night to type the urgent letter") 8. (34) discover, find -- (make a discovery, make a new finding; "Roentgen discovered X-rays"; "Physicists believe they found a new elementary particle") 9. (29) discover, find -- (make a discovery; "She found that he had lied to her"; "The story is false, so far as I can discover") 10. (16) find -- (obtain through effort or management; "She found the time and energy to take care of her aging parents"; "We found the money to send our sons to college") 11. (16) rule, find -- (decide on and make a declaration about; "find someone guilty") 12. (13) receive, get, find, obtain, incur -- (receive a specified treatment (abstract); "These aspects of civilization do not find expression or receive an interpretation"; "His movie received a good review"; "I got nothing but trouble for my good intentions") 13. (11) find -- (perceive oneself to be in a certain condition or place; "I found myself in a difficult situation"; "When he woke up, he found himself in a hospital room") 14. recover, retrieve, find, regain -- (get or find back; recover the use of; "She regained control of herself"; "She found her voice and replied quickly") 15. find -- (succeed in reaching; arrive at; "The arrow found its mark") 16. find oneself, find -- (accept and make use of one's personality, abilities, and situation; "My son went to Berkeley to find himself") Overview of adj found The adj found has 1 sense (first 1 from tagged texts) 1. (1) found -- (come upon unexpectedly or after searching; "found art"; "the lost-and-found department") --- WordNet end ---