ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [no cache]
500 found
22) Four lines with abnormal cortical axon development were also identified, one of which was found by whole-genome resequencing to carry a mutation in Lrp2.
* A forward genetic screen in mice identifies mutants with abnormal cortical patterning.
- Formation of a 6-layered cortical plate and axon tract patterning are key features of cerebral cortex development. Abnormalities of these processes may be the underlying cause for a range of functional disabilities seen in human neurodevelopmental disorders. To identify mouse mutants with defects in cortical lamination or corticofugal axon guidance, N-ethyl-N-nitrosourea (ENU) mutagenesis was performed using mice expressing LacZ reporter genes in layers II/III and V of the cortex (Rgs4-lacZ) or in corticofugal axons (TAG1-tau-lacZ). Four lines with abnormal cortical lamination have been identified. One of these was a splice site mutation in reelin (Reln) that results in a premature stop codon and the truncation of the C-terminal region (CTR) domain of reelin. Interestingly, this novel allele of Reln did not display cerebellar malformation or ataxia, and this is the first report of a Reln mutant without a cerebellar defect. Four lines with abnormal cortical axon development were also identified, one of which was found by whole-genome resequencing to carry a mutation in Lrp2. These findings demonstrated that the application of ENU mutagenesis to mice carrying transgenic reporters marking cortical anatomy is a sensitive and specific method to identify mutations that disrupt patterning of the developing brain.
=>設立する, 基礎づける
Overview of noun found
The noun found has 1 sense (first 1 from tagged texts)
1. (1) found -- (food and lodging provided in addition to money; "they worked for $30 and found")
Overview of verb found
The verb found has 3 senses (first 2 from tagged texts)
1. (9) establish, set up, found, launch -- (set up or found; "She set up a literacy program")
2. (4) establish, found, plant, constitute, institute -- (set up or lay the groundwork for;
"establish a new department")
3. establish, base, ground, found -- (use as a basis for; found on; "base a claim on some
observation")
Overview of verb find
The verb find has 16 senses (first 13 from tagged texts)
1. (159) find, happen, chance, bump, encounter -- (come upon, as if by accident; meet with; "We find
this idea in Plato"; "I happened upon the most wonderful bakery not very far from here"; "She
chanced upon an interesting book in the bookstore the other day")
2. (141) detect, observe, find, discover, notice -- (discover or determine the existence, presence,
or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in
the paint")
3. (86) find, regain -- (come upon after searching; find the location of something that was missed
or lost; "Did you find your glasses?"; "I cannot find my gloves!")
4. (57) determine, find, find out, ascertain -- (establish after a calculation, investigation,
experiment, survey, or study; "find the product of two numbers"; "The physicist who found the
elusive particle won the Nobel Prize")
5. (57) find, feel -- (come to believe on the basis of emotion, intuitions, or indefinite grounds;
"I feel that he doesn't like me"; "I find him to be obnoxious"; "I found the movie rather
entertaining")
6. (45) witness, find, see -- (perceive or be contemporaneous with; "We found Republicans winning
the offices"; "You'll see a lot of cheating in this school"; "The 1960's saw the rebellion of the
younger generation against established traditions"; "I want to see results")
7. (41) line up, get hold, come up, find -- (get something or somebody for a specific purpose; "I
found this gadget that will serve as a bottle opener"; "I got hold of these tools to fix our
plumbing"; "The chairman got hold of a secretary on Friday night to type the urgent letter")
8. (34) discover, find -- (make a discovery, make a new finding; "Roentgen discovered X-rays";
"Physicists believe they found a new elementary particle")
9. (29) discover, find -- (make a discovery; "She found that he had lied to her"; "The story is
false, so far as I can discover")
10. (16) find -- (obtain through effort or management; "She found the time and energy to take care
of her aging parents"; "We found the money to send our sons to college")
11. (16) rule, find -- (decide on and make a declaration about; "find someone guilty")
12. (13) receive, get, find, obtain, incur -- (receive a specified treatment (abstract); "These
aspects of civilization do not find expression or receive an interpretation"; "His movie received a
good review"; "I got nothing but trouble for my good intentions")
13. (11) find -- (perceive oneself to be in a certain condition or place; "I found myself in a
difficult situation"; "When he woke up, he found himself in a hospital room")
14. recover, retrieve, find, regain -- (get or find back; recover the use of; "She regained control
of herself"; "She found her voice and replied quickly")
15. find -- (succeed in reaching; arrive at; "The arrow found its mark")
16. find oneself, find -- (accept and make use of one's personality, abilities, and situation; "My
son went to Berkeley to find himself")
Overview of adj found
The adj found has 1 sense (first 1 from tagged texts)
1. (1) found -- (come upon unexpectedly or after searching; "found art"; "the lost-and-found
department")
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