kwic
found
found
left
off
ON
159
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for found out of >500 occurrences
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [no cache] 500 found
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of prior(left) word to found]
581812 occurrences (No.15 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 159) No differences were found between genotypes in the water-maintained behavior schedule or preference for non-alcohol tastants. |
| PMID:23855434 DOI:10.1111/adb.12076 |
| 2015 Addiction biology |
| * Role of cannabinoid CB2 receptor in the reinforcing actions of ethanol. |
| - This study examines the role of the cannabinoid CB2 receptor (CB2 r) on the vulnerability to ethanol consumption. The time-related and dose-response effects of ethanol on rectal temperature, handling-induced convulsions (HIC) and blood ethanol concentrations were evaluated in CB2 KO and wild-type (WT) mice. The reinforcing properties of ethanol were evaluated in conditioned place preference (CPP), preference and voluntary ethanol consumption and oral ethanol self-administration. Water-maintained behavior schedule was performed to evaluate the degree of motivation induced by a natural stimulus. Preference for non-alcohol tastants assay was performed to evaluate the differences in taste sensitivity. Tyrosine hydroxylase (TH) and μ-opioid receptor gene expressions were also measured in the ventral tegmental area and nucleus accumbens (NAcc), respectively. CB2 KO mice presented increased HIC score, ethanol-CPP, voluntary ethanol consumption and preference, acquisition of ethanol self-administration, and increased motivation to drink ethanol compared with WT mice. No differences were found between genotypes in the water-maintained behavior schedule or preference for non-alcohol tastants. Naïve CB2 KO mice presented increased μ-opioid receptor gene expression in NAcc. Acute ethanol administration (1-2 g/kg) increased TH and μ-opioid receptor gene expressions in CB2 KO mice, whereas the lower dose of ethanol decreased TH gene expression in WT mice. These results suggest that deletion of the CB2 r gene increased preference for and vulnerability to ethanol consumption, at least in part, by increased ethanol-induced sensitivity of the TH and μ-opioid receptor gene expressions in mesolimbic neurons. Future studies will determine the role of CB2 r as a target for the treatment of problems related with alcohol consumption. |
[
left
kwic]
(1)143 was |
(6)22 been |
(11)6 are |
(16)3 that |
| (2)110 were |
(7)12 and |
(12)5 be |
(17)2 analysis |
| (3)46 We |
(8)10 is |
(13)5 those |
(18)2 as |
| (4)29 we |
(9)10 not |
(14)3 authors |
(19)2 examination |
| (5)25 also |
(10)10 study |
(15)3 have |
add keyword
--- WordNet output for found ---