* Porous collagen-hydroxyapatite scaffolds with mesenchymal stem cells for bone regeneration.
- Current bone grafting materials have significant limitations for repairing maxillofacial and dentoalveolar bone deficiencies. An ideal bone tissue-engineering construct is still lacking. The purpose of the present study was first to synthesize and develop a collagen-hydroxyapatite (Col-HA) composite through controlled in situ mineralization on type I collagen fibrils with nanometer-sized apatite crystals, and then evaluate their biologic properties by culturing with mouse and human mesenchymal stem cells (MSCs). We synthesized Col-HA scaffolds with different Col:HA ratios. Mouse C3H10T1/2 MSCs and human periodontal ligament stem cells (hPDSCs) were cultured with scaffolds for cell proliferation and biocompatibility assays. We found that the porous Col-HA composites have good biocompatibility and biomimetic properties. The Col-HA composites with ratios 80:20 and 50:50 composites supported the attachments and proliferations of mouse MSCs and hPDSCs. These findings indicate that Col-HA composite complexes have strong potentials for bone tissue regeneration.
=>研究(調査)結果
Overview of noun findings
The noun findings has 1 sense (no senses from tagged texts)
1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or
clothing or shoes)
Overview of noun finding
The noun finding has 3 senses (first 3 from tagged texts)
1. (16) determination, finding -- (the act of determining the properties of something, usually by
research or calculation; "the determination of molecular structures")
2. (3) finding -- (the decision of a court on issues of fact or law)
3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate
that he died several hours after dinner"; "an area rich in archaeological findings")
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