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299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [no cache] 500 found

325) Our findings show that the Zn(2+) -chelating agent tricine slowly raises DA levels when perfused in the nucleus accumbens (nAc), whereas the more potent Zn(2+) chelator TPEN reduces DA levels.

--- ABSTRACT ---

PMID:24102995 DOI:10.1111/adb.12096

2015 Addiction biology

* Alterations in ethanol-induced accumbal transmission after acute and long-term zinc depletion.

- Alcoholism is subject to extensive research, but the role of changes in metabolism caused by alcohol consumption has been poorly investigated. Zinc (Zn(2+) ) deficiency is a common metabolic aberration among alcoholics and Zn(2+) influences the function of ligand-gated ion channels, known pharmacological targets of ethanol (EtOH). Here, we investigate whether manipulation of extracellular levels of Zn(2+) modulates EtOH-induced increases of dopamine (DA) output, as measured by in vivo microdialysis in the rat, and whether voluntary EtOH consumption is altered by Zn(2+) deficiency. Our findings show that the Zn(2+) -chelating agent tricine slowly raises DA levels when perfused in the nucleus accumbens (nAc), whereas the more potent Zn(2+) chelator TPEN reduces DA levels. We also show that pre-treatment with either tricine or TPEN blocks the EtOH-induced DA elevation. Chronic Zn(2+) deficiency induced by a Zn(2+) -free diet did not affect EtOH consumption, but excitatory transmission, assessed by striatal field-potential recordings in the nAc shell, was significantly modulated both by Zn(2+) -free diet and by EtOH consumption, as compared with the EtOH naïve controls. The present study indicates that Zn(2+) influences EtOH's interaction with the brain reward system, possibly by interfering with glycine receptor and GABAA receptor function. This also implies that Zn(2+) deficiency among alcoholics may be important to correct in order to normalize important aspects of brain function.

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(1)88 suggest	(15)10 revealed	(29)3 for	(43)2 during
(2)27 indicate	(16)9 may	(30)3 highlighted	(44)2 give
(3)24 of	(17)8 show	(31)3 imply	(45)2 hold
(4)23 null	(18)7 showed	(32)3 indicated	(46)2 implicate
(5)23 from	(19)7 underscore	(33)3 regarding	(47)2 into
(6)17 are	(20)6 to	(34)3 that	(48)2 is
(7)17 support	(21)5 suggested	(35)3 the	(49)2 lend
(8)14 provide	(22)4 also	(36)3 will	(50)2 or
(9)12 have	(23)4 included	(37)2 add	(51)2 point
(10)12 highlight	(24)4 on	(38)2 at	(52)2 provided
(11)12 in	(25)4 reveal	(39)2 by	(53)2 related
(12)12 were	(26)4 we	(40)2 call	(54)2 should
(13)11 and	(27)3 could	(41)2 confirm	(55)2 suggesting
(14)10 demonstrate	(28)3 demonstrated	(42)2 contribute	(56)2 suggestive

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--- WordNet output for findings --- =>研究(調査)結果 Overview of noun findings The noun findings has 1 sense (no senses from tagged texts) 1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or clothing or shoes) Overview of noun finding The noun finding has 3 senses (first 3 from tagged texts) 1. (16) determination, finding -- (the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures") 2. (3) finding -- (the decision of a court on issues of fact or law) 3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate that he died several hours after dinner"; "an area rich in archaeological findings") --- WordNet end ---