ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for findings out of >500 occurrences
299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [no cache] 500 found
319) These findings may have important implications for understanding the potential health effects of metal nanoparticle exposure.
--- ABSTRACT ---
PMID:24277352 DOI:10.1002/tox.21926
2015 Environmental toxicology
* Up-regulation of Gadd45α after exposure to metal nanoparticles: the role of hypoxia inducible factor 1α.
- The increased development and use of nanoparticles in various fields may lead to increased exposure, directly affecting human health. Our current knowledge of the health effects of metal nanoparticles such as cobalt and titanium dioxide (Nano-Co and Nano-TiO2 ) is limited but suggests that some metal nanoparticles may cause genotoxic effects including cell cycle arrest, DNA damage, and apoptosis. The growth arrest and DNA damage-inducible 45α protein (Gadd45α) has been characterized as one of the key players in the cellular responses to a variety of DNA damaging agents. The aim of this study was to investigate the alteration of Gadd45α expression in mouse embryo fibroblasts (PW) exposed to metal nanoparticles and the possible mechanisms. Non-toxic doses of Nano-Co and Nano-TiO2 were selected to treat cells. Our results showed that Nano-Co caused a dose- and time-dependent increase in Gadd45α expression, but Nano-TiO2 did not. To investigate the potential pathways involved in Nano-Co-induced Gadd45α up-regulation, we measured the expression of hypoxia inducible factor 1α (HIF-1α) in PW cells exposed to Nano-Co and Nano-TiO2 . Our results showed that exposure to Nano-Co caused HIF-1α accumulation in the nucleus. In addition, hypoxia inducible factor 1α knock-out cells [HIF-1α (-/-)] and its wild-type cells [HIF-1α (+/+)] were used. Our results demonstrated that Nano-Co caused a dose- and time-dependent increase in Gadd45α expression in wild-type HIF-1α (+/+) cells, but only a slight increase in HIF-1α (-/-) cells. Pre-treatment of PW cells with heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), prior to exposure to Nano-Co significantly abolished Nano-Co-induced Gadd45α expression. These results suggest that HIF-1α accumulation may be partially involved in the increased Gadd45α expression in cells exposed to Nano-Co. These findings may have important implications for understanding the potential health effects of metal nanoparticle exposure.
--- ABSTRACT END ---
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(1)88 suggest (15)10 revealed (29)3 for (43)2 during
(2)27 indicate (16)9 may (30)3 highlighted (44)2 give
(3)24 of (17)8 show (31)3 imply (45)2 hold
(4)23 *null* (18)7 showed (32)3 indicated (46)2 implicate
(5)23 from (19)7 underscore (33)3 regarding (47)2 into
(6)17 are (20)6 to (34)3 that (48)2 is
(7)17 support (21)5 suggested (35)3 the (49)2 lend
(8)14 provide (22)4 also (36)3 will (50)2 or
(9)12 have (23)4 included (37)2 add (51)2 point
(10)12 highlight (24)4 on (38)2 at (52)2 provided
(11)12 in (25)4 reveal (39)2 by (53)2 related
(12)12 were (26)4 we (40)2 call (54)2 should
(13)11 and (27)3 could (41)2 confirm (55)2 suggesting
(14)10 demonstrate (28)3 demonstrated (42)2 contribute (56)2 suggestive

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--- WordNet output for findings --- =>研究(調査)結果 Overview of noun findings The noun findings has 1 sense (no senses from tagged texts) 1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or clothing or shoes) Overview of noun finding The noun finding has 3 senses (first 3 from tagged texts) 1. (16) determination, finding -- (the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures") 2. (3) finding -- (the decision of a court on issues of fact or law) 3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate that he died several hours after dinner"; "an area rich in archaeological findings") --- WordNet end ---