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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for findings out of >500 occurrences
299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [no cache] 500 found
229) These findings provide new information into the possible correlation between Ago2/miRs complex regulation and DA neurons plasticity during opiate addiction.
--- ABSTRACT ---
PMID:23927484 DOI:10.1111/adb.12083
2015 Addiction biology
* Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons.
- Epigenetic changes such as microRNAs (miRs)/Ago2-induced gene silencing represent complex molecular signature that regulate cellular plasticity. Recent studies showed involvement of miRs and Ago2 in drug addiction. In this study, we show that changes in gene expression induced by morphine and morphine withdrawal occur with concomitant epigenetic modifications in the mesolimbic dopaminergic (DA) pathway [ventral tegmental area (VTA)/nucleus accumbens (NAc) shell], which is critically involved in drug-induced dependence. We found that acute or chronic morphine administration as well as morphine withdrawal did not modify miR-133b messenger RNA (mRNA) expression in the VTA, whereas Ago2 protein levels were decreased and increased in morphine-dependent rats and after morphine withdrawal, respectively. These changes were paralleled with enhanced and decreased NAc tyrosine hydroxylase (TH) protein (an early DA marker) in morphine-dependent rats and after withdrawal, respectively. We also observed changes in TH mRNA expression in the VTA that could be related to Ago2-induced translational repression of TH mRNA during morphine withdrawal. However, the VTA number of TH-positive neurons suffered no alterations after the different treatment. Acute morphine administration produced a marked increase in TH activity and DA turnover in the NAc (shell). In contrast, precipitated morphine withdrawal decreased TH activation and did not change DA turnover. These findings provide new information into the possible correlation between Ago2/miRs complex regulation and DA neurons plasticity during opiate addiction.
--- ABSTRACT END ---
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(2)27 indicate (16)9 may (30)3 highlighted (44)2 give
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(4)23 *null* (18)7 showed (32)3 indicated (46)2 implicate
(5)23 from (19)7 underscore (33)3 regarding (47)2 into
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(7)17 support (21)5 suggested (35)3 the (49)2 lend
(8)14 provide (22)4 also (36)3 will (50)2 or
(9)12 have (23)4 included (37)2 add (51)2 point
(10)12 highlight (24)4 on (38)2 at (52)2 provided
(11)12 in (25)4 reveal (39)2 by (53)2 related
(12)12 were (26)4 we (40)2 call (54)2 should
(13)11 and (27)3 could (41)2 confirm (55)2 suggesting
(14)10 demonstrate (28)3 demonstrated (42)2 contribute (56)2 suggestive

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--- WordNet output for findings --- =>研究(調査)結果 Overview of noun findings The noun findings has 1 sense (no senses from tagged texts) 1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or clothing or shoes) Overview of noun finding The noun finding has 3 senses (first 3 from tagged texts) 1. (16) determination, finding -- (the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures") 2. (3) finding -- (the decision of a court on issues of fact or law) 3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate that he died several hours after dinner"; "an area rich in archaeological findings") --- WordNet end ---