ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
kwic search for findings out of >500 occurrences
299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [cache]
22) These findings suggest that ERK1/2 activation has a pivotal role in IP-induced changes in TJs and inflammatory response, which serve to protect against BBB breakdown and inflammation after ischemic stroke.
* Extracellular signal-regulated kinase1/2-dependent changes in tight junctions after ischemic preconditioning contributes to tolerance induction after ischemic stroke.
- Less disruption of the blood-brain barrier (BBB) after severe ischemic stroke is one of the beneficial outcomes of ischemic preconditioning (IP). However, the effect of IP on tight junctions (TJs), which regulate paracellular permeability of the BBB, is not well understood. In the present study, we examined IP-induced changes in TJs before and after middle cerebral artery occlusion (MCAO) in mice, and the association between changes in TJs and tolerance to a subsequent insult. After IP, we found decreased levels of transmembrane TJ proteins occludin and claudin-5, and widened gaps of TJs with perivascular swelling at the ultrastructural level in the brain. An inflammatory response was also observed. These changes were reversed by inhibition of extracellular signal-regulated kinase1/2 (ERK1/2) via the specific ERK1/2 inhibitor U0126. After MCAO, reduced brain edema and inflammatory responses were associated with altered levels of angiogenic factors and cytokines in preconditioned brains. Pretreatment with U0126 reversed the neuroprotective effects of IP against MCAO. These findings suggest that ERK1/2 activation has a pivotal role in IP-induced changes in TJs and inflammatory response, which serve to protect against BBB breakdown and inflammation after ischemic stroke.
Overview of noun findings
The noun findings has 1 sense (no senses from tagged texts)
1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or
clothing or shoes)
Overview of noun finding
The noun finding has 3 senses (first 3 from tagged texts)
1. (16) determination, finding -- (the act of determining the properties of something, usually by
research or calculation; "the determination of molecular structures")
2. (3) finding -- (the decision of a court on issues of fact or law)
3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate
that he died several hours after dinner"; "an area rich in archaeological findings")
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PubMed database: last updated on 2021-04-11 (c)sirasawa 2019