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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for findings out of >500 occurrences
299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [no cache] 500 found
206) These findings support a function of OPN in mediating TPA-induced neoplastic transformation of JB6 cells.
--- ABSTRACT ---
PMID:24249517 DOI:10.1002/mc.22108
2015 Molecular carcinogenesis
* Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.
- Osteopontin (OPN), an adhesive, matricellular glycoprotein, is a rate-limiting factor in tumor promotion of skin carcinogenesis. With a tumor promotion model, the JB6 Cl41.5a cell line, we have shown that suppressing 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced OPN expression markedly inhibits TPA-induced colony formation in soft agar, an assay indicative of tumorigenic transformation. Further, the addition of exogenous OPN promotes colony formation of these cells. These findings support a function of OPN in mediating TPA-induced neoplastic transformation of JB6 cells. In regard to the mechanism of action by OPN, we hypothesized that, for JB6 cells grown in soft-agar, secreted OPN induced by TPA stimulates cell proliferation and/or prevents anoikis to facilitate TPA-induced colony formation. Analyses of cell cycle and cyclin D1 expression, and direct cell counting of JB6 cells treated with OPN indicate that OPN does not stimulate cell proliferation relative to non-treated controls. Instead, at 24 h, OPN decreases anoikis by 41%, as assessed by annexin V assays. Further, in suspended cells OPN suppresses caspase-8 activation, which is mediated specifically through its RGD-cell binding motif that transduces signals through integrin receptors. Transfection studies with wild-type and mutant focal adhesion kinases (FAK) and Western blot analyses suggest that OPN suppression of caspase-8 activation is mediated through phosphorylation of FAK at Tyr(861). In summary, these studies indicate that induced OPN is a microenvironment modulator that facilitates tumorigenic transformation of JB6 cells by inhibiting anoikis through its RGD-dependent suppression of caspase-8 activity, which is mediated in part through the activation of FAK at Tyr(861).
--- ABSTRACT END ---
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(2)27 indicate (16)9 may (30)3 highlighted (44)2 give
(3)24 of (17)8 show (31)3 imply (45)2 hold
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(9)12 have (23)4 included (37)2 add (51)2 point
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(11)12 in (25)4 reveal (39)2 by (53)2 related
(12)12 were (26)4 we (40)2 call (54)2 should
(13)11 and (27)3 could (41)2 confirm (55)2 suggesting
(14)10 demonstrate (28)3 demonstrated (42)2 contribute (56)2 suggestive

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--- WordNet output for findings --- =>研究(調査)結果 Overview of noun findings The noun findings has 1 sense (no senses from tagged texts) 1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or clothing or shoes) Overview of noun finding The noun finding has 3 senses (first 3 from tagged texts) 1. (16) determination, finding -- (the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures") 2. (3) finding -- (the decision of a court on issues of fact or law) 3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate that he died several hours after dinner"; "an area rich in archaeological findings") --- WordNet end ---