2015 Journal of tissue engineering and regenerative medicine
* Processed xenogenic cartilage as innovative biomatrix for cartilage tissue engineering: effects on chondrocyte differentiation and function.
- One key point in the development of new bioimplant matrices for the reconstruction and replacement of cartilage defects is to provide an adequate microenvironment to ensure chondrocyte migration and de novo synthesis of cartilage-specific extracellular matrix (ECM). A recently developed decellularization and sterilization process maintains the three-dimensional (3D) collagen structure of native septal cartilage while increasing matrix porosity, which is considered to be crucial for cartilage tissue engineering. Human primary nasal septal chondrocytes were amplified in monolayer culture and 3D-cultured on processed porcine nasal septal cartilage scaffolds. The influence of chondrogenic growth factors on neosynthesis of ECM proteins was examined at the protein and gene expression levels. Seeding experiments demonstrated that processed xenogenic cartilage matrices provide excellent environmental properties for human nasal septal chondrocytes with respect to cell adhesion, migration into the matrix and neosynthesis of cartilage-specific ECM proteins, such as collagen type II and aggrecan. Matrix biomechanical stability indicated that the constructs retrieve full stability and function during 3D culture for up to 42 days, proportional to collagen type II and GAG production. Thus, processed xenogenic cartilage offers a suitable environment for human nasal chondrocytes and has promising potential for cartilage tissue engineering in the head and neck region.
Overview of noun factor
The noun factor has 7 senses (first 4 from tagged texts)
1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined
the outcome")
2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something;
"jealousy was a component of his character"; "two constituents of a musical composition are melody
and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an
effective ingredient of a speech")
3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another
integer; "what are the 4 factors of 6?")
4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a
commission)
5. factor -- (any of the numbers (or symbols) that form a product when multiplied together)
6. factor -- (an independent variable in statistics)
7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide
chain; it can include regions preceding and following the coding DNA as well as introns between the
exons; it is considered a unit of heredity; "genes were formerly called factors")
Overview of verb factor
The verb factor has 3 senses (first 1 from tagged texts)
1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the
number 15")
2. factor -- (be a contributing factor; "make things factor into a company's profitability")
3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor
in the recent developments")
--- WordNet end ---