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295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [cache]

191) We further measured the gene expression by qRT-PCR regarding growth factors and matrixmetalloproteinases (MMPs) involved in regeneration processes.

--- ABSTRACT ---

PMID:23517467 DOI:10.1111/iwj.12069

2015 International wound journal

* Acute and chronic wound fluids influence keratinocyte function differently.

- Wound healing requires a proper functioning of keratinocytes that migrate, proliferate and lead to a competent wound closure. Impaired wound healing might be due to a disturbed keratinocyte function caused by the wound environment. Basically, chronic wound fluid (CWF) differs from acute wound fluid (AWF). The aim of this study was to analyse the effects of AWF and CWF on keratinocyte function. We therefore investigated keratinocyte migration and proliferation under the influence of AWF and CWF using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test and scratch assay. We further measured the gene expression by qRT-PCR regarding growth factors and matrixmetalloproteinases (MMPs) involved in regeneration processes. AWF had a positive impact on keratinocyte proliferation over time, whereas CWF had an anti-proliferative effect. Keratinocyte migration was significantly impaired by CWF in contrast to an undisturbed wound closure under the influence of AWF. MMP-9 expression was strongly upregulated by CWF compared with AWF. Keratinocyte function was significantly impaired by CWF. An excessive induction of MMP-9 by CWF might lead to a permanent degradation of extracellular matrix and thereby prevent wounds from healing.

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(1)62 for	(12)10 related	(23)3 using	(34)2 during
(2)44 null	(13)8 on	(24)3 which	(35)2 from
(3)36 that	(14)7 have	(25)3 with	(36)2 including
(4)34 associated	(15)7 such	(26)2 (age,	(37)2 independently
(5)31 and	(16)6 may	(27)2 along	(38)2 involved
(6)29 in	(17)4 influence	(28)2 as	(39)2 jointly
(7)20 were	(18)4 significantly	(29)2 c-Jun	(40)2 other
(8)14 influencing	(19)4 to	(30)2 can	(41)2 produced
(9)13 are	(20)3 across	(31)2 contribute	(42)2 was
(10)13 of	(21)3 among	(32)2 contributing
(11)10 affecting	(22)3 like	(33)2 diagnostic

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---