ELIZA

return kwic search for factors out of >500 occurrences
295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [no cache] 500 found

163) We discuss current analytical challenges for the identification and quantification of chemicals and their metabolites, both stable and reactive, focusing especially on LC-MS techniques, but simultaneously attempting to pinpoint factors associated with sample preparation, testing conditions and strengths and weaknesses of a particular technique available for a particular task.

--- ABSTRACT ---

PMID:23994130 DOI:10.1016/j.tox.2013.08.010

2015 Toxicology

* Analytical challenges for conducting rapid metabolism characterization for QIVIVE.

- For quantitative in vitro-in vivo extrapolation (QIVIVE) of metabolism for the purposes of toxicokinetics prediction, a precise and robust analytical technique for identifying and measuring a chemical and its metabolites is an absolute prerequisite. Currently, high-resolution mass spectrometry (HR-MS) is a tool of choice for a majority of organic relatively lipophilic molecules, linked with a LC separation tool and simultaneous UV-detection. However, additional techniques such as gas chromatography, radiometric measurements and NMR, are required to cover the whole spectrum of chemical structures. To accumulate enough reliable and robust data for the validation of QIVIVE, there are some partially opposing needs: Detailed delineation of the in vitro test system to produce a reliable toxicokinetic measure for a studied chemical, and a throughput capacity of the in vitro set-up and the analytical tool as high as possible. We discuss current analytical challenges for the identification and quantification of chemicals and their metabolites, both stable and reactive, focusing especially on LC-MS techniques, but simultaneously attempting to pinpoint factors associated with sample preparation, testing conditions and strengths and weaknesses of a particular technique available for a particular task.

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[frequency of next (right) word to factors]

(1)62 for	(12)10 related	(23)3 using	(34)2 during
(2)44 null	(13)8 on	(24)3 which	(35)2 from
(3)36 that	(14)7 have	(25)3 with	(36)2 including
(4)34 associated	(15)7 such	(26)2 (age,	(37)2 independently
(5)31 and	(16)6 may	(27)2 along	(38)2 involved
(6)29 in	(17)4 influence	(28)2 as	(39)2 jointly
(7)20 were	(18)4 significantly	(29)2 c-Jun	(40)2 other
(8)14 influencing	(19)4 to	(30)2 can	(41)2 produced
(9)13 are	(20)3 across	(31)2 contribute	(42)2 was
(10)13 of	(21)3 among	(32)2 contributing
(11)10 affecting	(22)3 like	(33)2 diagnostic

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---