ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for expression of out of >500 occurrences
286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found
24) The accurate expression of the genetic information is regulated by processes like mRNA splicing, proposed after the discoveries of Phil Sharp and Richard Roberts, who demonstrated the existence of intronic sequences, present in almost every structural eukaryotic gene, which should be precisely removed.
--- ABSTRACT ---
PMID:24725854 DOI:10.1016/j.medcli.2014.02.021
2015 Medicina clinica
* [Alternative splicing regulation: implications in cancer diagnosis and treatment].
- The accurate expression of the genetic information is regulated by processes like mRNA splicing, proposed after the discoveries of Phil Sharp and Richard Roberts, who demonstrated the existence of intronic sequences, present in almost every structural eukaryotic gene, which should be precisely removed. This intron removal is called "splicing", which generates different proteins from a single mRNA, with different or even antagonistic functions. We currently know that alternative splicing is the most important source of protein diversity, given that 70% of the human genes undergo splicing and that mutations causing defects in this process could originate up to 50% of genetic diseases, including cancer. When these defects occur in genes involved in cell adhesion, proliferation and cell cycle regulation, there is an impact on cancer progression, rising the opportunity to diagnose and treat some types of cancer according to a particular splicing profile.
--- ABSTRACT END ---
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(1)55 the (15)3 key (29)2 P-selectin, (44)2 cell
(2)11 a (16)3 multiple (30)2 P2X3 (45)2 constitutively
(3)9 genes (17)3 ncRAN (32)2 Sema (46)2 hyaluronan
(4)8 several (18)3 nicotine-induced (33)2 Siglec-9 (47)2 imprinted
(5)6 miR-218 (19)3 nuclear (34)2 TAF4 (48)2 intercellular
(6)5 these (20)3 specific (35)2 Wnt (49)2 membrane
(7)4 VEGF (21)3 this (36)2 acetyl-CoA (50)2 miR-128
(8)4 first (22)2 AdipoR1 (37)2 adhesion (51)2 napsin
(9)4 matrix (23)2 Caspase (38)2 adiponectin (52)2 phosphorylated
(10)3 CYP1A1 (24)2 FBP1 (39)2 angiogenic (53)2 piRNA-823
(11)3 DNMT1 (25)2 GABAA (40)2 anti-apoptotic (54)2 pro-inflammatory
(12)3 all (26)2 GLP-1R (41)2 b-FGF, (55)2 some
(13)3 cardiac (27)2 Ki-67, (42)2 c-Myc (56)2 three
(14)3 integrin (28)2 LOX-1 (43)2 cartilage

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--- WordNet output for expression --- =>表現すること, 式, 表現, 表示, 言い回し, 表現法, 表情 Overview of noun expression The noun expression has 9 senses (first 6 from tagged texts) 1. (23) expression, look, aspect, facial expression, face -- (the feelings expressed on a person's face; "a sad expression"; "a look of triumph"; "an angry face") 2. (18) expression, manifestation, reflection, reflexion -- (expression without words; "tears are an expression of grief"; "the pulse is a reflection of the heart's condition") 3. (15) expression, verbal expression, verbalism -- (the communication (in speech or writing) of your beliefs or opinions; "expressions of good will"; "he helped me find verbal expression for my ideas"; "the idea was immediate but the verbalism took hours") 4. (5) saying, expression, locution -- (a word or phrase that particular people use in particular situations; "pardon the expression") 5. (4) formulation, expression -- (the style of expressing yourself; "he suggested a better formulation"; "his manner of expression showed how much he cared") 6. (4) formula, expression -- (a group of symbols that make a mathematical statement) 7. expression -- ((genetics) the process of expressing a gene) 8. construction, grammatical construction, expression -- (a group of words that form a constituent of a sentence and are considered as a single unit; "I concluded from his awkward constructions that he was a foreigner") 9. expression -- (the act of forcing something out by squeezing or pressing; "the expression of milk from her breast") --- WordNet end ---