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286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found
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286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 136) LPS augmented the expression of nuclear factor of activated T-cells (NFATc1) as a key transcription factor of osteoclastogenesis in cells maintained in RPMI-1640 medium, but reduced it in cells maintained in α-MEM. |
| PMID:24595208 DOI:10.1177/1753425914524242 |
| 2015 Innate immunity |
| * Involvement of redox balance in in vitro osteoclast formation of RAW 264.7 macrophage cells in response to LPS. |
| - Here we report that LPS induces osteoclast (OC) formation in murine RAW 264.7 macrophage cells in RPMI-1640 medium but not in α-minimum essential medium (α-MEM) as the original culture medium. LPS-induced OC formation in both media was examined to clarify the differential response. Receptor activator of NF-κB ligand induced OC formation in either α-MEM or RPMI-1640 medium. However, LPS-induced OC formation in RAW 264.7 cells maintained in RPMI-1640 medium, but not α-MEM, which was also supported by mouse bone marrow-derived macrophages, although they were less sensitive to LPS than RAW 264.7 cells. LPS augmented the expression of nuclear factor of activated T-cells (NFATc1) as a key transcription factor of osteoclastogenesis in cells maintained in RPMI-1640 medium, but reduced it in cells maintained in α-MEM. A high concentration of LPS was cytotoxic against cells maintained in α-MEM. Glutathione exclusively present in RPMI-1640 medium prevented LPS-induced cell death in α-MEM and augmented LPS-induced NFATc1 expression, followed by enhanced LPS-induced OC formation. LPS induced higher generation of reactive oxygen species in α-MEM than RPMI-1640 medium. An antioxidant enhanced LPS-induced OC formation, whereas a pro-oxidant reduced it. Taken together, redox balance in the culture condition was suggested to regulate in vitro LPS-induced OC formation. |
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(1)55  the |
(15)3 key |
(29)2 P-selectin, |
(44)2 cell |
| (2)11 a |
(16)3 multiple |
(30)2 P2X3 |
(45)2 constitutively |
| (3)9 genes |
(17)3 ncRAN |
(32)2 Sema |
(46)2 hyaluronan |
| (4)8 several |
(18)3 nicotine-induced |
(33)2 Siglec-9 |
(47)2 imprinted |
| (5)6 miR-218 |
(19)3 nuclear |
(34)2 TAF4 |
(48)2 intercellular |
| (6)5 these |
(20)3 specific |
(35)2 Wnt |
(49)2 membrane |
| (7)4 VEGF |
(21)3 this |
(36)2 acetyl-CoA |
(50)2 miR-128 |
| (8)4 first |
(22)2 AdipoR1 |
(37)2 adhesion |
(51)2 napsin |
| (9)4 matrix |
(23)2 Caspase |
(38)2 adiponectin |
(52)2 phosphorylated |
| (10)3 CYP1A1 |
(24)2 FBP1 |
(39)2 angiogenic |
(53)2 piRNA-823 |
| (11)3 DNMT1 |
(25)2 GABAA |
(40)2 anti-apoptotic |
(54)2 pro-inflammatory |
| (12)3 all |
(26)2 GLP-1R |
(41)2 b-FGF, |
(55)2 some |
| (13)3 cardiac |
(27)2 Ki-67, |
(42)2 c-Myc |
(56)2 three |
| (14)3 integrin |
(28)2 LOX-1 |
(43)2 cartilage |
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