kwic
effects+of
effects+of
right
off
ON
210
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for effects of out of >500 occurrences
291610 occurrences (No.83 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to effects of]
291610 occurrences (No.83 in the rank) during 5 years in the PubMed. [cache]
| 210) In this study, we investigated the effects of β-NF on the antioxidant defense systems of the intertidal copepod Tigriopus japonicus. |
| PMID:24136887 DOI:10.1002/tox.21911 |
| 2015 Environmental toxicology |
| * β-Naphthoflavone induces oxidative stress in the intertidal copepod, Tigriopus japonicus. |
| - β-Naphtoflavone (β-NF) is a flavonoid and enhances oxidative stress in vertebrates with little information from aquatic invertebrates as yet. In this study, we investigated the effects of β-NF on the antioxidant defense systems of the intertidal copepod Tigriopus japonicus. To measure the β-NF-triggered changes in oxidative stress markers, such as intracellular reactive oxygen species (ROS), glutathione (GSH) concentration, residual glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR), and superoxide dismutase (SOD) activity, T. japonicus were exposed to β-NF (0.5 and 1 mg/L) for 72 h. Significant (P < 0.05) induction of the intracellular ROS content (%) was observed in 1 mg/L of β-NF exposed T. japonicus, compared to the negative control and H2O2-exposed group. The GSH levels were significantly increased in the 0.5 mg/L of β-NF-exposed group for 12 h and 1 mg/L of β-NF-exposed groups for 12-24 h. GPx, GST, and GR activities showed a significant increase in the 1 mg/L β-NF-exposed group, indicating that β-NF induces oxidative stress in T. japonicus. To understand the effects of β-NF at the level of transcript expression, a 6K microarray analysis was employed. Transcript profiles of selected antioxidant-related genes were modulated after 72 h exposure to 1 mg/L of β-NF. From microarray data, 10 GST isoforms, GR, GPx, PH-GPx, and Se-GPx were chosen for a time-course test by real-time RT-PCR. T. japonicus GST-S, GST-O, GST-M, and GST-D1 were significantly increased in a 1 mg/L β-NF-exposed group. T. japonicus GPx, GR, and Se-GPx mRNA levels were also significantly increased at both concentrations. Our results revealed that oxidative stress was induced by β-NF exposure in T. japonicus. |
[
right
kwic]
(1)38  the |
(17)3 nicotine, |
(33)2 childhood |
(49)2 nicotine |
| (2)12 these |
(18)3 three |
(34)2 chronic |
(50)2 oral |
| (3)7 a |
(19)3 two |
(35)2 coping |
(51)2 oxidized |
| (4)5 an |
(20)2 10 |
(36)2 dietary |
(52)2 prolonged |
| (5)5 different |
(21)2 2 |
(37)2 environmental |
(53)2 reappraisal |
| (6)5 exposure |
(22)2 CUX1 |
(38)2 fungal |
(54)2 resilience |
| (7)5 this |
(23)2 DADS |
(39)2 heavy |
(55)2 resistance |
| (8)4 CP |
(24)2 DEHP |
(40)2 individual |
(56)2 scaffold |
| (9)4 HLs |
(25)2 EMF |
(41)2 ionizing |
(57)2 self-determined |
| (10)4 TV |
(26)2 LLLT |
(42)2 length |
(58)2 social |
| (11)4 both |
(27)2 NPs |
(43)2 low |
(59)2 subacute |
| (12)4 perceived |
(28)2 Ni |
(44)2 mercury |
(60)2 tramadol, |
| (13)3 black-odor |
(29)2 SLT |
(45)2 mesenchymal |
(61)2 various |
| (14)3 changes |
(30)2 administration |
(46)2 metal |
(62)2 vitamin |
| (15)3 exercise |
(31)2 age |
(47)2 methanolic |
(63)2 wheat |
| (16)3 long-term |
(32)2 caffeic |
(48)2 multivitamins |
add keyword
--- WordNet output for effects ---