* 2-Photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca(2+) in intact mice, rat, and rabbit hearts.
- We describe a novel two-photon (2P) laser scanning microscopy (2PLSM) protocol that provides ratiometric transmural measurements of membrane voltage (Vm ) via Di-4-ANEPPS in intact mouse, rat and rabbit hearts with subcellular resolution. The same cells were then imaged with Fura-2/AM for intracellular Ca(2+) recordings. Action potentials (APs) were accurately characterized by 2PLSM vs. microelectrodes, albeit fast events (<1 ms) were sub-optimally acquired by 2PLSM due to limited sampling frequencies (2.6 kHz). The slower Ca(2+) transient (CaT) time course (>1ms) could be accurately described by 2PLSM. In conclusion, Vm - and Ca(2+) -sensitive dyes can be 2P excited within the cardiac muscle wall to provide AP and Ca(2+) signals to ∼400 µm.
=>1.予定の, 支払期日がきて, 当然支払われるべき, 2.支払[提出]期日, 満期日, 会費
Overview of noun due
The noun due has 2 senses (first 1 from tagged texts)
1. (4) due -- (that which is deserved or owed; "give the devil his due")
2. due -- (a payment that is due (e.g., as the price of membership); "the society dropped him for
non-payment of dues")
Overview of adj due
The adj due has 4 senses (first 2 from tagged texts)
1. (6) due -- (owed and payable immediately or on demand; "payment is due")
2. (1) due -- (scheduled to arrive; "the train is due in 15 minutes")
3. due -- (suitable to or expected in the circumstances; "all due respect"; "due cause to honor
them"; "a long due promotion"; "in due course"; "due esteem"; "exercising due care")
4. ascribable, due, imputable, referable -- (capable of being assigned or credited to; "punctuation
errors ascribable to careless proofreading"; "the cancellation of the concert was due to the rain";
"the oversight was not imputable to him")
Overview of adv due
The adv due has 1 sense (no senses from tagged texts)
1. due -- (directly or exactly; straight; "went due North")
--- WordNet end ---