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319715 occurrences (No.67 in the rank) during 5 years in the PubMed. [no cache] 500 found

146) Due to their multifunctional properties, solid lipid nanoparticles (SLNs) have received great attention of scientists to find a solution to cancer.

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PMID:24344935 DOI:10.3109/10837450.2013.867447

2015 Pharmaceutical development and technology

* Vitamin B12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy.

- Nanostructure-mediated drug delivery, a key technology for the realization of nanomedicine, has the potential to improve drug bioavailability, ameliorate release deviation of drug molecules and enable precision drug targeting. Due to their multifunctional properties, solid lipid nanoparticles (SLNs) have received great attention of scientists to find a solution to cancer. Vitamin supplements may contribute to a reduction in the risk of cancer. Vitamin B12 has several characteristics that make it an attractive entity for cancer treatment and possible therapeutic applications. The aim of this study was to produce B12-loaded SLNs (B12-SLNs) and determine the cytotoxic effects of B12-SLNs on H-Ras 5RP7 and NIH/3T3 control cell line. Results obtained by MTT assay, transmission electron and confocal microscopy showed that B12-loaded SLNs are more effective than free vitamin B12 on cancer cells. In addition, characterization studies indicate that while the average diameter of the B12 was about 650 nm, B12-SLNs were about 200 nm and the drug release efficiency of vit. B12 by means of SLNs increased up to 3 h. These observations point to the fact that B12-SLNs could be used as carrier systems due to the therapeutic effects on cancer.

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[frequency of next (right) word to due to]

(1)115 the	(10)4 insufficient	(19)2 cardiac	(28)2 pannus
(2)30 its	(11)3 changes	(20)2 common	(29)2 potential
(3)30 their	(12)3 increased	(21)2 condom	(30)2 previous
(4)20 a	(13)3 low	(22)2 environmental	(31)2 primary
(5)9 an	(14)3 multiple	(23)2 extreme	(32)2 progressive
(6)5 limited	(15)3 poor	(24)2 inadequate	(33)2 prolonged
(7)4 differences	(16)3 possible	(25)2 inflammation	(34)2 similarities
(8)4 different	(17)2 abnormal	(26)2 lack	(35)2 some
(9)4 high	(18)2 anthropogenic	(27)2 major

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--- WordNet output for due --- =>1.予定の, 支払期日がきて, 当然支払われるべき, 2.支払[提出]期日, 満期日, 会費 Overview of noun due The noun due has 2 senses (first 1 from tagged texts) 1. (4) due -- (that which is deserved or owed; "give the devil his due") 2. due -- (a payment that is due (e.g., as the price of membership); "the society dropped him for non-payment of dues") Overview of adj due The adj due has 4 senses (first 2 from tagged texts) 1. (6) due -- (owed and payable immediately or on demand; "payment is due") 2. (1) due -- (scheduled to arrive; "the train is due in 15 minutes") 3. due -- (suitable to or expected in the circumstances; "all due respect"; "due cause to honor them"; "a long due promotion"; "in due course"; "due esteem"; "exercising due care") 4. ascribable, due, imputable, referable -- (capable of being assigned or credited to; "punctuation errors ascribable to careless proofreading"; "the cancellation of the concert was due to the rain"; "the oversight was not imputable to him") Overview of adv due The adv due has 1 sense (no senses from tagged texts) 1. due -- (directly or exactly; straight; "went due North") --- WordNet end ---