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21) Due to repeated blood transfusions, he developed platelet transfusion refractoriness (PTR) to platelets from cross-matched donors as well as random donors.
* Successful use of rituximab in platelet transfusion refractoriness in a multi-transfused patient with myelodysplastic syndrome.
- A 61-year-old man with newly diagnosed INT-1 risk myelodysplastic syndrome--refractory cytopenia with multilineage dysplasia (MDS-RCMD) was not responsive to treatment, such as androgen, thalidomide, granulocyte--colony stimulating factor (G-CSF) combined with erythropoietin (EPO), interleukin-11 (IL-11) and thrombopoietin (TPO), and became transfusion dependent. Due to repeated blood transfusions, he developed platelet transfusion refractoriness (PTR) to platelets from cross-matched donors as well as random donors. Anti-HLA class I antibodies were positive with enzyme-linked immunosorbent assay; however, HLA-compatible platelet products were unavailable. PTR was unresponsive to high-dose immunoglobulin and plasma exchange. The patient was then treated with rituximab 375 mg/m(2) on days 1 and 8, and 100 mg total dose on days 15 and 22. Already after the first dose of rituximab, the patient was able to received successful platelet transfusion from all donors. Therefore rituximab may be considered as a potential therapy for PTR.
=>1.予定の, 支払期日がきて, 当然支払われるべき, 2.支払[提出]期日, 満期日, 会費
Overview of noun due
The noun due has 2 senses (first 1 from tagged texts)
1. (4) due -- (that which is deserved or owed; "give the devil his due")
2. due -- (a payment that is due (e.g., as the price of membership); "the society dropped him for
non-payment of dues")
Overview of adj due
The adj due has 4 senses (first 2 from tagged texts)
1. (6) due -- (owed and payable immediately or on demand; "payment is due")
2. (1) due -- (scheduled to arrive; "the train is due in 15 minutes")
3. due -- (suitable to or expected in the circumstances; "all due respect"; "due cause to honor
them"; "a long due promotion"; "in due course"; "due esteem"; "exercising due care")
4. ascribable, due, imputable, referable -- (capable of being assigned or credited to; "punctuation
errors ascribable to careless proofreading"; "the cancellation of the concert was due to the rain";
"the oversight was not imputable to him")
Overview of adv due
The adv due has 1 sense (no senses from tagged texts)
1. due -- (directly or exactly; straight; "went due North")
--- WordNet end ---