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422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [no cache] 500 found
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422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 392) Methylation of E-cadherin was significantly correlated with different stage of disease (p < 0.05). |
| PMID:23572389 DOI:10.1177/0748233713484657 |
| 2015 Toxicology and industrial health |
| * Hypermethylation of P15, P16, and E-cadherin genes in ovarian cancer. |
| - Both p16 and p15 proteins are inhibitors of cyclin-dependent kinases that prevent the cell going through the G1/S phase transaction. E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent interactions between adjacent epithelial cells. Two groups of patients were selected: the first group suffered from epithelial serous ovarian tumors and the second group suffered from benign ovarian lesions; ovarian tissue samples from all the subjects (benign and malignant) were subjected to methylation-specific polymerase chain reaction for methylated and unmethylated alleles of the genes (E-cadherin, p15, and p16). Results obtained showed that aberrant methylation of p15 and p16 genes were detected in 64.29 and 50% of ovarian cancer patients, while E-cadherin hypermethylation was detected in 78.57% of ovarian cancer patients. Methylation of E-cadherin was significantly correlated with different stage of disease (p < 0.05). It was found that the risk of E-cadherin hypermethylation was 1.347-fold, while risk of p15 hypermethylation was 1.543-fold and p16 was 1.2-fold among patients with ovarian cancer than that among patients with benign ovarian lesions. In conclusion, Dysfunction of the cell cycle and/or the cell-cell adhesion molecule plays a role in the pathogenesis of ovarian cancer and that the analysis of the methylation of p15 and E-cadherin genes can provide clinically important evidence on which to base the treatment. |
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| (1)100 *null* | (17)4  (PD) |
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(49)2 condition, |
| (2)39 and |
(18)4 activity |
(34)2 (CHD) |
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| (3)16 is |
(19)4 outcome |
(35)2 (COPD) |
(51)2 interval |
| (4)13 in |
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(36)2 (CVD), |
(52)2 many |
| (5)12 of |
(21)4 the |
(37)2 (GERD) |
(53)2 multi-sectoral |
| (6)9 (FMD) |
(22)4 who |
(38)2 (LSD) |
(54)2 on |
| (7)8 risk |
(23)3 (CAD) |
(39)2 (SC) |
(55)2 onset |
| (8)7 severity |
(24)3 compared |
(40)2 Control |
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(25)3 control |
(41)2 activity, |
(57)2 outbreaks |
| (10)6 that |
(26)3 course |
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(58)2 patterns |
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(27)3 free |
(43)2 as |
(59)2 phobia |
| (12)5 (CVD) |
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(60)2 prevention |
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(29)3 management |
(45)2 burden |
(61)2 processes |
| (14)5 state |
(30)3 may |
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| (15)4 (AD) |
(31)3 patients |
(47)2 can |
(63)2 surveillance |
| (16)4 (HD) |
(32)3 states |
(48)2 characterized |
(64)2 usually |
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--- WordNet output for disease ---