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683276 occurrences (No.7 in the rank) during 5 years in the PubMed. [no cache] 500 found

65) Acrylamide induced nociceptive pain sensitive changes, which have been assessed by hot plate, Von Frey Hair, and tail immersion tests at different time intervals, that is, 0, 6, 12, 18, and 24th day.

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PMID:23719848 DOI:10.1177/0748233713491808

2015 Toxicology and industrial health

* Pharmacological evaluation of methanolic leaf extract of Swietenia mahagoni on acrylamide-induced neuropathic pain in rats.

- The present study was designed to investigate the antinociceptive effects of methanolic leaf extract of Swietenia mahagoni (MESM) on acrylamide-induced painful neuropathy in rats. The intraperitoneal administration of acrylamide (30 mg/kg; for 24 consecutive days) has been employed for the induction of painful neuropathy. Acrylamide induced nociceptive pain sensitive changes, which have been assessed by hot plate, Von Frey Hair, and tail immersion tests at different time intervals, that is, 0, 6, 12, 18, and 24th day. Furthermore, the biochemical changes, that is, thiobarbituric acid-reactive substances, reduced glutathione, and total calcium levels have been estimated in sciatic nerve tissue on 24th day and histopathological changes have been observed in sciatic nerve tissue sample. MESM and pregabalin have been administered for 14 consecutive days before 1 h of the each acrylamide injection. Administration of acrylamide resulted in significant changes in behavioral and biochemical parameters. Pretreatment of MESM ameliorated acrylamide-induced behavioral, biochemical, and histopathological changes in a dose-dependent manner, which is similar to that of pregabalin-pretreated group. These findings suggested that the neuroprotective effect of S. mahagoni may be due to its potential of antioxidative, calcium channel modulatory, and neuroprotective action.

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(1)21 from	(18)3 amounts	(35)2 compared	(52)2 origins
(2)15 types	(19)3 aspects	(36)2 dietary	(53)2 output
(3)10 between	(20)3 cell	(37)2 diseases	(54)2 pHs
(4)9 doses	(21)3 degrees	(38)2 dosing	(55)2 patterns
(5)7 concentrations	(22)3 effects	(39)2 ethnic	(56)2 perspectives
(6)6 time	(23)3 for	(40)2 flow	(57)2 protocols
(7)5 in	(24)3 health	(41)2 frequencies	(58)2 range
(8)5 levels	(25)3 mechanisms	(42)2 gene	(59)2 regions
(9)4 null	(26)3 parts	(43)2 genes	(60)2 scenarios
(10)4 areas	(27)3 roles	(44)2 genetic	(61)2 sensory
(11)4 combinations	(28)3 species	(45)2 human	(62)2 surface
(12)4 components	(29)3 ways	(46)2 indicators	(63)2 taxa
(13)4 groups	(30)2 abutments	(47)2 internal-cone	(64)2 than
(14)4 methods	(31)2 and	(48)2 laser	(65)2 therapeutic
(15)4 stages	(32)2 approaches	(49)2 masking	(66)2 tissues
(16)4 tilt	(33)2 bleaching	(50)2 materials	(67)2 versions
(17)3 adhesive	(34)2 changes	(51)2 molecular	(68)2 views

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--- WordNet output for different --- =>いろいろな, 違った, 異なった, 様々の, 種々の, 異なる, 変わった Overview of adj different The adj different has 5 senses (first 4 from tagged texts) 1. (88) different -- (unlike in nature or quality or form or degree; "took different approaches to the problem"; "came to a different conclusion"; "different parts of the country"; "on different sides of the issue"; "this meeting was different from the earlier one") 2. (41) different -- (distinctly separate from the first; "that's another (or different) issue altogether") 3. (2) different -- (differing from all others; not ordinary; "advertising that strives continually to be different"; "this new music is certainly different but I don't really like it") 4. (1) unlike, dissimilar, different -- (marked by dissimilarity; "for twins they are very unlike"; "people are profoundly different") 5. different -- (distinct or separate; "each interviewed different members of the community") --- WordNet end ---