ELIZA

return kwic search for different out of >500 occurrences
683276 occurrences (No.7 in the rank) during 5 years in the PubMed. [no cache] 500 found

42) Inhibition was dose-dependent and not significantly different between forskolin or cilostamide treatment.

--- ABSTRACT ---

PMID:24115212 DOI:10.1002/mc.22091

2015 Molecular carcinogenesis

* Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.

- Aggressive dissemination and metastasis of pancreatic ductal adenocarcinoma (PDAC) results in poor prognosis and marked lethality. Rho monomeric G protein levels are increased in pancreatic cancer tissue. As the mechanisms underlying PDAC malignancy are little understood, we investigated the role for cAMP in regulating monomeric G protein regulated invasion and migration of pancreatic cancer cells. Treatment of PDAC cells with cAMP elevating agents that activate adenylyl cyclases, forskolin, protein kinase A (PKA), 6-Bnz-cAMP, or the cyclic nucleotide phosphodiesterase inhibitor cilostamide significantly decreased migration and Matrigel invasion of PDAC cell lines. Inhibition was dose-dependent and not significantly different between forskolin or cilostamide treatment. cAMP elevating drugs not only blocked basal migration, but similarly abrogated transforming-growth factor-β-directed PDAC cell migration and invasion. The inhibitory effects of cAMP were prevented by the pharmacological blockade of PKA. Drugs that increase cellular cAMP levels decreased levels of active RhoA or RhoC, with a concomitant increase in phosphorylated RhoA. Diminished Rho signaling was correlated with the appearance of thickened cortical actin bands along the perimeter of non-motile forskolin or cilostamide-treated cells. Decreased migration did not reflect alterations in cell growth or programmed cell death. Collectively these data support the notion that increased levels of cAMP specifically hinder PDAC cell motility through F-actin remodeling.

--- ABSTRACT END ---

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(1)21 from	(18)3 amounts	(35)2 compared	(52)2 origins
(2)15 types	(19)3 aspects	(36)2 dietary	(53)2 output
(3)10 between	(20)3 cell	(37)2 diseases	(54)2 pHs
(4)9 doses	(21)3 degrees	(38)2 dosing	(55)2 patterns
(5)7 concentrations	(22)3 effects	(39)2 ethnic	(56)2 perspectives
(6)6 time	(23)3 for	(40)2 flow	(57)2 protocols
(7)5 in	(24)3 health	(41)2 frequencies	(58)2 range
(8)5 levels	(25)3 mechanisms	(42)2 gene	(59)2 regions
(9)4 null	(26)3 parts	(43)2 genes	(60)2 scenarios
(10)4 areas	(27)3 roles	(44)2 genetic	(61)2 sensory
(11)4 combinations	(28)3 species	(45)2 human	(62)2 surface
(12)4 components	(29)3 ways	(46)2 indicators	(63)2 taxa
(13)4 groups	(30)2 abutments	(47)2 internal-cone	(64)2 than
(14)4 methods	(31)2 and	(48)2 laser	(65)2 therapeutic
(15)4 stages	(32)2 approaches	(49)2 masking	(66)2 tissues
(16)4 tilt	(33)2 bleaching	(50)2 materials	(67)2 versions
(17)3 adhesive	(34)2 changes	(51)2 molecular	(68)2 views

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--- WordNet output for different --- =>いろいろな, 違った, 異なった, 様々の, 種々の, 異なる, 変わった Overview of adj different The adj different has 5 senses (first 4 from tagged texts) 1. (88) different -- (unlike in nature or quality or form or degree; "took different approaches to the problem"; "came to a different conclusion"; "different parts of the country"; "on different sides of the issue"; "this meeting was different from the earlier one") 2. (41) different -- (distinctly separate from the first; "that's another (or different) issue altogether") 3. (2) different -- (differing from all others; not ordinary; "advertising that strives continually to be different"; "this new music is certainly different but I don't really like it") 4. (1) unlike, dissimilar, different -- (marked by dissimilarity; "for twins they are very unlike"; "people are profoundly different") 5. different -- (distinct or separate; "each interviewed different members of the community") --- WordNet end ---