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683276 occurrences (No.7 in the rank) during 5 years in the PubMed. [no cache] 500 found

247) Even with the same amount of tinnitus-related distress level, responsible neural substrates are different according to the onset age.

--- ABSTRACT ---

PMID:24135769 DOI:10.1007/s00429-013-0648-x

2015 Brain structure & function

* Onset-related differences in neural substrates of tinnitus-related distress: the anterior cingulate cortex in late-onset tinnitus, and the frontal cortex in early-onset tinnitus.

- Recent findings regarding differences in tinnitus-related neural activity according to onset age have raised a question on possible onset age-related differences in neural substrates of distress. Hence we collected quantitative electroencephalography (qEEG) findings of 28 late-onset tinnitus (LOT) and 29 early-onset tinnitus (EOT) (mean onset age 52.3 and 29.0 years, respectively) participants. According to the tinnitus questionnaire (TQ) score grade, LOTs were then subdivided into 13 high distress (HD; TQ grade 3 or 4) and 15 low distress (LD; TQ grade 1 or 2), while EOTs into 14 HD and 15 LD. Compared to the EOT group, the LOT group demonstrated increased qEEG source-localized activity and functional connectivity primarily in the anterior cingulate cortex (ACC) and parahippocampus. In subgroup comparisons, the ACC was activated more in HD-LOT participants than in LD-LOT participants for the beta 1, beta 2 and gamma frequency bands, while the left orbitofrontal cortex and left dorsolateral prefrontal cortex were activated more in HD-EOT than in LD-EOT for the delta/beta and gamma frequency bands, respectively. Even with the same amount of tinnitus-related distress level, responsible neural substrates are different according to the onset age. These differences may be important for exploring different target areas of treatment according to tinnitus onset age, as well as for conducting similar studies on other pathologies, such as depression or pain.

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(1)21 from	(18)3 amounts	(35)2 compared	(52)2 origins
(2)15 types	(19)3 aspects	(36)2 dietary	(53)2 output
(3)10 between	(20)3 cell	(37)2 diseases	(54)2 pHs
(4)9 doses	(21)3 degrees	(38)2 dosing	(55)2 patterns
(5)7 concentrations	(22)3 effects	(39)2 ethnic	(56)2 perspectives
(6)6 time	(23)3 for	(40)2 flow	(57)2 protocols
(7)5 in	(24)3 health	(41)2 frequencies	(58)2 range
(8)5 levels	(25)3 mechanisms	(42)2 gene	(59)2 regions
(9)4 null	(26)3 parts	(43)2 genes	(60)2 scenarios
(10)4 areas	(27)3 roles	(44)2 genetic	(61)2 sensory
(11)4 combinations	(28)3 species	(45)2 human	(62)2 surface
(12)4 components	(29)3 ways	(46)2 indicators	(63)2 taxa
(13)4 groups	(30)2 abutments	(47)2 internal-cone	(64)2 than
(14)4 methods	(31)2 and	(48)2 laser	(65)2 therapeutic
(15)4 stages	(32)2 approaches	(49)2 masking	(66)2 tissues
(16)4 tilt	(33)2 bleaching	(50)2 materials	(67)2 versions
(17)3 adhesive	(34)2 changes	(51)2 molecular	(68)2 views

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--- WordNet output for different --- =>いろいろな, 違った, 異なった, 様々の, 種々の, 異なる, 変わった Overview of adj different The adj different has 5 senses (first 4 from tagged texts) 1. (88) different -- (unlike in nature or quality or form or degree; "took different approaches to the problem"; "came to a different conclusion"; "different parts of the country"; "on different sides of the issue"; "this meeting was different from the earlier one") 2. (41) different -- (distinctly separate from the first; "that's another (or different) issue altogether") 3. (2) different -- (differing from all others; not ordinary; "advertising that strives continually to be different"; "this new music is certainly different but I don't really like it") 4. (1) unlike, dissimilar, different -- (marked by dissimilarity; "for twins they are very unlike"; "people are profoundly different") 5. different -- (distinct or separate; "each interviewed different members of the community") --- WordNet end ---