ELIZA

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683276 occurrences (No.7 in the rank) during 5 years in the PubMed. [no cache] 500 found

146) In this chapter we focus on the enzyme catalyzing the activation of sialic acid, the CMP-sialic acid synthetase (CMAS), and compare the enzymatic properties of CMASs isolated from different species.

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PMID:24141690 DOI:10.1007/128_2013_477

2015 Topics in current chemistry

* CMP-Sialic Acid Synthetase: The Point of Constriction in the Sialylation Pathway.

- Sialoglycoconjugates form the outermost layer of animal cells and play a crucial role in cellular communication processes. An essential step in the biosynthesis of sialylated glycoconjugates is the activation of sialic acid to the monophosphate diester CMP-sialic acid. Only the activated sugar is transported into the Golgi apparatus and serves as a substrate for the linkage-specific sialyltransferases. Interference with sugar activation abolishes sialylation and is embryonic lethal in mammals. In this chapter we focus on the enzyme catalyzing the activation of sialic acid, the CMP-sialic acid synthetase (CMAS), and compare the enzymatic properties of CMASs isolated from different species. Information concerning the reaction mechanism and active site architecture is included. Moreover, the unusual nuclear localization of vertebrate CMASs as well as the biotechnological application of bacterial CMAS enzymes is addressed.

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(1)21 from	(18)3 amounts	(35)2 compared	(52)2 origins
(2)15 types	(19)3 aspects	(36)2 dietary	(53)2 output
(3)10 between	(20)3 cell	(37)2 diseases	(54)2 pHs
(4)9 doses	(21)3 degrees	(38)2 dosing	(55)2 patterns
(5)7 concentrations	(22)3 effects	(39)2 ethnic	(56)2 perspectives
(6)6 time	(23)3 for	(40)2 flow	(57)2 protocols
(7)5 in	(24)3 health	(41)2 frequencies	(58)2 range
(8)5 levels	(25)3 mechanisms	(42)2 gene	(59)2 regions
(9)4 null	(26)3 parts	(43)2 genes	(60)2 scenarios
(10)4 areas	(27)3 roles	(44)2 genetic	(61)2 sensory
(11)4 combinations	(28)3 species	(45)2 human	(62)2 surface
(12)4 components	(29)3 ways	(46)2 indicators	(63)2 taxa
(13)4 groups	(30)2 abutments	(47)2 internal-cone	(64)2 than
(14)4 methods	(31)2 and	(48)2 laser	(65)2 therapeutic
(15)4 stages	(32)2 approaches	(49)2 masking	(66)2 tissues
(16)4 tilt	(33)2 bleaching	(50)2 materials	(67)2 versions
(17)3 adhesive	(34)2 changes	(51)2 molecular	(68)2 views

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--- WordNet output for different --- =>いろいろな, 違った, 異なった, 様々の, 種々の, 異なる, 変わった Overview of adj different The adj different has 5 senses (first 4 from tagged texts) 1. (88) different -- (unlike in nature or quality or form or degree; "took different approaches to the problem"; "came to a different conclusion"; "different parts of the country"; "on different sides of the issue"; "this meeting was different from the earlier one") 2. (41) different -- (distinctly separate from the first; "that's another (or different) issue altogether") 3. (2) different -- (differing from all others; not ordinary; "advertising that strives continually to be different"; "this new music is certainly different but I don't really like it") 4. (1) unlike, dissimilar, different -- (marked by dissimilarity; "for twins they are very unlike"; "people are profoundly different") 5. different -- (distinct or separate; "each interviewed different members of the community") --- WordNet end ---