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9) In addition, the description of the "serrated pathway" has shifted the focus of interest also towards to sessile serrated adenomas and traditional serrated adenomas in the development of CRC.
- Colorectal cancer (CRC) is the most frequent gastrointestinal tumour. Most CRC appear to arise from adenomas of the colon in a period of 10 or 15 years. The ultimately progression of benign adenomas to malignant CRC is known as the adenoma-carcinoma sequence. In addition, the description of the "serrated pathway" has shifted the focus of interest also towards to sessile serrated adenomas and traditional serrated adenomas in the development of CRC. It has been proven that the screening colonoscopy might prevent CRC by early detection of adenomatous polyps as precursors for colorectal cancer and polypectomy. Thus, disease-associated mortality of CRC could be reduced. Colonoscopy, the gold standard in CRC diagnosis, is recommended to men and women from the age of 55. On the one hand, there are requirements to the endoscopists. On the other hand there are also essential requirements to pathologists' findings. After polypectomy a risk stratification for aftercare based on endoscopic and histological findings is necessary. Endoscopic follow-up of high-risk patients (≥ 3 tubular adenomas, ≥ 1 adenoma ≥ 1 cm, tubulovillous or villous adenoma, ≥ 1 adenoma with high-grade intraepithelial neoplasia, ≥ 10 adenoma no matter what size or histological findings) should be done sooner (< 3 years). In contrast, colonoscopy in low-risk patients (1 or 2 [tubular] adenomas, size < 1 cm) should be performed later rather than sooner (> 5 years). Colonoscopic surveys under 12 months should be done only in exceptional and very serious situations. Pharmaceutical chemoprevention of adenomas or CRC are still part of clinical trails. More data are necessary.
=>発達, 開発, 産物, 進展
Overview of noun development
The noun development has 9 senses (first 7 from tagged texts)
1. (52) development -- (act of improving by expanding or enlarging or refining; "he congratulated
them on their development of a plan to meet the emergency"; "they funded research and development")
2. (46) development, evolution -- (a process in which something passes by degrees to a different
stage (especially a more advanced or mature stage); "the development of his ideas took many years";
"the evolution of Greek civilization"; "the slow development of her skill as a writer")
3. (11) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of
an individual organism growing organically; a purely biological unfolding of events involved in an
organism changing gradually from a simple to a more complex level; "he proposed an indicator of
osseous development in children")
4. (9) development -- (a recent event that has some relevance for the present situation; "recent
developments in Iraq"; "what a revolting development!")
5. (7) exploitation, development -- (the act of making some area of land or water more profitable or
productive or useful; "the development of Alaskan resources"; "the exploitation of copper deposits")
6. (6) development -- (a district that has been developed to serve some purpose; "such land is
practical for small park developments")
7. (4) development -- (a state in which things are improving; the result of developing (as in the
early part of a game of chess); "after he saw the latest development he changed his mind and became
a supporter"; "in chess your should take care of your development before moving your queen")
8. development, developing -- (processing a photosensitive material in order to make an image
visible; "the development and printing of his pictures took only two hours")
9. development -- ((music) the section of a composition or movement (especially in sonata form)
where the major musical themes are developed and elaborated)
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