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return kwic search for demonstrated out of >500 occurrences
286534 occurrences (No.87 in the rank) during 5 years in the PubMed. [no cache] 500 found

187) Gold accumulation in fish tissues demonstrated the lower bioavailability of AuNP compared to ionic Au, and underlined the higher toxic potential of the nanoparticle form.

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PMID:24559428 DOI:10.3109/17435390.2014.889238

2015 Nanotoxicology

* Impact of gold nanoparticles on zebrafish exposed to a spiked sediment.

- Increasing use of metallic nanomaterials is likely to result in release of these particles into aquatic environments; nevertheless it is unclear whether these materials present a hazard to aquatic organisms. The impact of contaminated sediment containing 14-nm gold nanoparticles (AuNPs) was investigated in the zebrafish Danio rerio exposed for 20 days to two concentrations, 16 and 55 µg/g dry weight. AuNPs were released from the sediment to the water column, and during this period the mean concentrations of AuNP in the filtered water fraction were 0.25 ± 0.05 and 0.8 ± 0.1 µg/L, respectively. A similar experiment with ionic gold contamination was simultaneously performed to obtain a positive control. AuNP exposure triggered various effects in fish tissues including modifications of genome composition, shown using a random amplified polymorphic DNA-PCR genotoxicity test. Expression of genes involved in oxidative stress, mitochondrial metabolism, detoxification and DNA repair were also modulated in response to AuNP contamination. Gold altered neurotransmission, since brain acetylcholine esterase activity increased for both tested doses of AuNP but not for ionic gold. Gold accumulation in fish tissues demonstrated the lower bioavailability of AuNP compared to ionic Au, and underlined the higher toxic potential of the nanoparticle form.

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[frequency of next (right) word to demonstrated]

(1)158 that	(10)5 good	(19)3 excellent	(28)2 efficacy
(2)48 the	(11)5 increased	(20)3 more	(29)2 greater
(3)40 a	(12)5 significantly	(21)3 no	(30)2 how
(4)23 by	(13)4 as	(22)3 that,	(31)2 successful
(5)21 to	(14)4 better	(23)2 acceptable	(32)2 through
(6)13 in	(15)4 improved	(24)2 and	(33)2 using
(7)12 null	(16)4 its	(25)2 both
(8)11 an	(17)4 similar	(26)2 decreased
(9)8 for	(18)3 between	(27)2 differential

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--- WordNet output for demonstrated --- Overview of verb demonstrate The verb demonstrate has 4 senses (first 4 from tagged texts) 1. (24) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (22) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an example, explanation or experiment; "The experiment demonstrated the instability of the compound"; "The mathematician showed the validity of the conjecture") 3. (2) attest, certify, manifest, demonstrate, evidence -- (provide evidence for; stand as proof of; show by one's behavior, attitude, or external attributes; "His high fever attested to his illness"; "The buildings in Rome manifest a high level of architectural sophistication"; "This decision demonstrates his sense of fairness") 4. (1) demonstrate, march -- (march in protest; take part in a demonstration; "Thousands demonstrated against globalization during the meeting of the most powerful economic nations in Seattle") Overview of adj demonstrated The adj demonstrated has 1 sense (first 1 from tagged texts) 1. (1) demonstrated -- (having been demonstrated or verified beyond doubt) --- WordNet end ---