251) The bacterial load of blood, liver, spleen and lung was significantly decreased within group D compared to group B at 36 hours. |
PMID:24548093 DOI:10.1179/1973947814Y.0000000171 |
2015 Journal of chemotherapy (Florence, Italy) |
* Comparative efficacy of tigecycline VERSUS vancomycin in an experimental model of soft tissue infection by methicillin-resistant Staphylococcus aureus producing Panton-Valentine leukocidin. |
- Methicillin-resistant Staphylococcus aureus (MRSA) producing Panton-Valentine leukocidin (PVL) is highly virulent. This study aimed to compare the efficacy of tigecycline versus vancomycin in experimental thigh abscess by a PVL-producing MRSA isolate. One hundred and ninety-six Wistar rats were divided into five groups: group A, controls; groups B and C, administered vancomycin starting 1 and 6 h after bacterial challenge respectively; groups D and E, administered tigecycline starting 1 and 6 h after bacterial challenge respectively. Treatment was continued every 12 hours for three consecutive days. Survival was recorded; separate animals were killed for quantitative cultures. Serum samples were collected for estimation of malondialdehyde (MDA). Survival of group D was prolonged compared to all other groups. The bacterial load of blood, liver, spleen and lung was significantly decreased within group D compared to group B at 36 hours. Treatment with tigecycline was accompanied by significant reduction of serum MDA at 24 hours. Tigecycline is comparable to vancomycin for the treatment of soft tissue infections by PVL-producing MRSA. |
(1)105 the | (10)6 conventional | (19)3 group | (28)2 groups |
(2)23 those | (11)5 controls, | (20)3 pure | (29)2 its |
(3)19 control | (12)5 placebo | (21)2 TCDD | (30)2 long |
(4)14 a | (13)5 untreated | (22)2 age-matched | (31)2 non-Hispanic |
(5)12 that | (14)4 Exo(Normoxic) | (23)2 baseline | (32)2 non-transgenic |
(6)10 controls | (15)4 all | (24)2 bur-prepared | (33)2 people |
(7)10 other | (16)4 patients | (25)2 children | (34)2 plain |
(8)9 healthy | (17)3 an | (26)2 controls), | (35)2 previous |
(9)9 their | (18)3 drug | (27)2 experimental | (36)2 vehicle |
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