ELIZA

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270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [no cache] 500 found

244) Orthotopic liver transplantation (OLT) recipients have been reported to have decreased perioperative opioid and intraoperative inhalational anesthetic requirements when compared to patients without liver disease undergoing other types of major abdominal surgeries.

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PMID:24521192 DOI:10.3109/21681805.2013.870602

2015 Current clinical pharmacology

* Analgesic considerations for liver transplantation patients.

- Orthotopic liver transplantation (OLT) recipients have been reported to have decreased perioperative opioid and intraoperative inhalational anesthetic requirements when compared to patients without liver disease undergoing other types of major abdominal surgeries. The severity of the liver disease and the process of the transplantation itself may alter the pharmacokinetic and pharmacodynamic effects of different pain medications. Chemical injury of the liver and the high degree of surgical stress may also increase the levels of neuropeptides involved in pain modulation. Per the U.S. Department of Health and Human Services Organ Procurement and Transplantation Network, more than 5,000 OLT cases are being done per year since 2000. With better understanding of the pathophysiology of liver disease and the development of perioperative anesthesia management, the recent concept of improving patient outcome following OLT includes a fast-track approach in selected patients, which may shorten or completely bypass intensive care unit stay and reduce costs. With this development, the understanding of the analgesic pharmacology in the care of the OLT patients is even more important. Proper dosage of medications can achieve adequate intraoperative anesthetic depth and postoperative pain control, while avoiding over-sedation which increases risk of prolonged postoperative mechanical ventilation. The purpose of this review is to summarize the pharmacokinetics and pharmacodynamics of the analgesic medications commonly administered to this patient population.

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(1)105 the	(10)6 conventional	(19)3 group	(28)2 groups
(2)23 those	(11)5 controls,	(20)3 pure	(29)2 its
(3)19 control	(12)5 placebo	(21)2 TCDD	(30)2 long
(4)14 a	(13)5 untreated	(22)2 age-matched	(31)2 non-Hispanic
(5)12 that	(14)4 Exo(Normoxic)	(23)2 baseline	(32)2 non-transgenic
(6)10 controls	(15)4 all	(24)2 bur-prepared	(33)2 people
(7)10 other	(16)4 patients	(25)2 children	(34)2 plain
(8)9 healthy	(17)3 an	(26)2 controls),	(35)2 previous
(9)9 their	(18)3 drug	(27)2 experimental	(36)2 vehicle

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--- WordNet output for compared --- =>前年同期比で(は) Overview of verb compare The verb compare has 4 senses (first 3 from tagged texts) 1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut to his friend's"; "We compared notes after we had both seen the movie") 2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes") 3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed") 4. compare -- (to form the comparative or superlative form on an adjective or adverb) --- WordNet end ---