ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for compared to out of >500 occurrences
270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [no cache] 500 found
222) NER and base excision repair genes were significantly under-expressed (P < 0.016) in patients at diagnosis compared to controls, in accordance with reduced NER function (P = 0.008) and increased SBs (P = 0.015).
--- ABSTRACT ---
PMID:24585457 DOI:10.1002/mc.22141
2015 Molecular carcinogenesis
* Post-treatment recovery of suboptimal DNA repair capacity and gene expression levels in colorectal cancer patients.
- DNA repair in blood cells was observed to be suboptimal in cancer patients at diagnosis, including colorectal cancer (CRC). To explore the causality of this phenomenon, we studied the dynamics of DNA repair from diagnosis to 1 yr follow-up, and with respect to CRC treatment. Systemic CRC therapy is targeted to DNA damage induction and DNA repair is thus of interest. CRC patients were blood-sampled three times in 6-mo intervals, starting at the diagnosis, and compared to healthy controls. DNA repair was characterized by mRNA levels of 40 repair genes, by capacity of nucleotide excision repair (NER), and by levels of DNA strand breaks (SBs). NER and base excision repair genes were significantly under-expressed (P < 0.016) in patients at diagnosis compared to controls, in accordance with reduced NER function (P = 0.008) and increased SBs (P = 0.015). Six months later, there was an increase of NER capacity, but not of gene expression levels, in treated patients only. A year from diagnosis, gene expression profiles and NER capacity were significantly modified in all patients and were no longer different from those measured in controls. All patients were free of relapse at the last sampling, so we were unable to clarify the impact of DNA repair parameters on treatment response. However, we identified a panel of blood DNA repair-related markers discerning acute stage of the disease from the remission period. In conclusion, our results support a model in which DNA repair is altered as a result of cancer.
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(1)105 the (10)6 conventional (19)3 group (28)2 groups
(2)23 those (11)5 controls, (20)3 pure (29)2 its
(3)19 control (12)5 placebo (21)2 TCDD (30)2 long
(4)14 a (13)5 untreated (22)2 age-matched (31)2 non-Hispanic
(5)12 that (14)4 Exo(Normoxic) (23)2 baseline (32)2 non-transgenic
(6)10 controls (15)4 all (24)2 bur-prepared (33)2 people
(7)10 other (16)4 patients (25)2 children (34)2 plain
(8)9 healthy (17)3 an (26)2 controls), (35)2 previous
(9)9 their (18)3 drug (27)2 experimental (36)2 vehicle

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--- WordNet output for compared --- =>前年同期比で(は) Overview of verb compare The verb compare has 4 senses (first 3 from tagged texts) 1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut to his friend's"; "We compared notes after we had both seen the movie") 2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes") 3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed") 4. compare -- (to form the comparative or superlative form on an adjective or adverb) --- WordNet end ---