2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
* Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia.
- No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes.
Overview of verb compare
The verb compare has 4 senses (first 3 from tagged texts)
1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut
to his friend's"; "We compared notes after we had both seen the movie")
2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes")
3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can
compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed")
4. compare -- (to form the comparative or superlative form on an adjective or adverb)
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PubMed database: last updated on 2022-12-07 (c)sirasawa 2019