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return kwic search for compared to out of >500 occurrences
270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [no cache] 500 found

165) TCS in testes and prostates both showed a lower-level distribution compared to that in the plasma, which indicates it has no tendency to accumulate in those organs.

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PMID:23929691 DOI:10.1002/tox.21897

2015 Environmental toxicology

* Triclosan exhibits a tendency to accumulate in the epididymis and shows sperm toxicity in male Sprague-Dawley rats.

- Triclosan (TCS) is considered a potent endocrine disruptor that causes reproductive toxicity in non-mammals, but it is still unclear exactly whether TCS has adverse effects on the sperm or reproductive organs in mammals. In this study, we aimed to evaluate the distribution status of TCS in male reproductive organs of rats, and seek the correlation with the TCS-induced sperm toxicity or reproductive organ damage. Male rats were intragastrically administered with TCS at a dose of 50 mg/kg, the kinetics of TCS in the plasma and reproductive organs were investigated. TCS in testes and prostates both showed a lower-level distribution compared to that in the plasma, which indicates it has no tendency to accumulate in those organs. However, TCS in the epididymides showed a longer elimination half-life (t1/2 z), a longer the mean retention time (MRT), and a lower clearance (CLZ /F) compared with those in the plasma. Besides, the ratios of mean area under the concentration-time curve (AUC)(0-96 h(epididymides/plasma)) and AUC(0-∞(epididymides/plasma)) were 1.13 and 1.51, respectively. These kinetic parameters suggest TCS has an accumulation tendency in the epididymides. Based on this, we investigated the TCS-induced sperm toxicity and histopathological changes of reproductive organs in rats. TCS was given intragastrically at doses of 10, 50, and 200 mg/kg for 8 weeks. Rats treated with the high dose (200 mg/kg) of TCS showed a significant decrease in daily sperm production (DSP), changes in sperm morphology and epididymal histopathology. Considering the histopathological change in the epididymides, TCS may induce the epididymal damage due to the epididymal accumulation of that.

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(1)105 the	(10)6 conventional	(19)3 group	(28)2 groups
(2)23 those	(11)5 controls,	(20)3 pure	(29)2 its
(3)19 control	(12)5 placebo	(21)2 TCDD	(30)2 long
(4)14 a	(13)5 untreated	(22)2 age-matched	(31)2 non-Hispanic
(5)12 that	(14)4 Exo(Normoxic)	(23)2 baseline	(32)2 non-transgenic
(6)10 controls	(15)4 all	(24)2 bur-prepared	(33)2 people
(7)10 other	(16)4 patients	(25)2 children	(34)2 plain
(8)9 healthy	(17)3 an	(26)2 controls),	(35)2 previous
(9)9 their	(18)3 drug	(27)2 experimental	(36)2 vehicle

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--- WordNet output for compared --- =>前年同期比で(は) Overview of verb compare The verb compare has 4 senses (first 3 from tagged texts) 1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut to his friend's"; "We compared notes after we had both seen the movie") 2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes") 3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed") 4. compare -- (to form the comparative or superlative form on an adjective or adverb) --- WordNet end ---