138) Mice exposed to DE had substantially greater abundance of parenchymal IgG compared to control mice not exposed to DE. |
PMID:24477878 DOI:10.1002/jat.2985 |
2015 Journal of applied toxicology : JAT |
* The effect of diesel exhaust exposure on blood-brain barrier integrity and function in a murine model. |
- Epidemiological studies indicate that exposure to diesel exhaust (DE) is associated with vascular-based disorders. To investigate the effect of DE on blood-brain barrier (BBB) function and integrity, 8-week-old BALB/c mice were randomized to DE in a cyclical treatment regimen over a 2-week period. Functional integrity of BBB was determined by considering brain parenchymal abundance of IgG within the hippocampal formation and cortex at 6 h and 24 h intervals following final exposure treatment. Neurovascular inflammation was expressed as the abundance of glial fibrillar acidic protein. Two doses of DE were studied and compared to air-only treated mice. Mice exposed to DE had substantially greater abundance of parenchymal IgG compared to control mice not exposed to DE. Increased parenchymal glial fibrillar acidic protein at 24 h post-DE exposure suggested heightened neurovascular inflammation. Our findings are proof-of-concept that inhalation of DE can compromise BBB function and support the broader contention that DE exposure may contribute to neurovascular disease risk. |
(1)105 the | (10)6 conventional | (19)3 group | (28)2 groups |
(2)23 those | (11)5 controls, | (20)3 pure | (29)2 its |
(3)19 control | (12)5 placebo | (21)2 TCDD | (30)2 long |
(4)14 a | (13)5 untreated | (22)2 age-matched | (31)2 non-Hispanic |
(5)12 that | (14)4 Exo(Normoxic) | (23)2 baseline | (32)2 non-transgenic |
(6)10 controls | (15)4 all | (24)2 bur-prepared | (33)2 people |
(7)10 other | (16)4 patients | (25)2 children | (34)2 plain |
(8)9 healthy | (17)3 an | (26)2 controls), | (35)2 previous |
(9)9 their | (18)3 drug | (27)2 experimental | (36)2 vehicle |
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