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270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [no cache] 500 found

115) The therapeutic effect of hPSC-derived perivascular cells in experimental models of tissue engineering and regenerative medicine are described and compared to those of their native physiological counterparts.

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PMID:23365073 DOI:10.1002/term.1698

2015 Journal of tissue engineering and regenerative medicine

* Therapeutic potential of perivascular cells from human pluripotent stem cells.

- Vascularization of injured tissues or artificial grafts is a major challenge in tissue engineering, stimulating a continued search for alternative sources for vasculogenic cells and the development of therapeutic strategies. Human pluripotent stem cells (hPSCs), either embryonic or induced, offer a plentiful platform for the derivation of large numbers of vasculogenic cells, as required for clinical transplantations. Various protocols for generation of vasculogenic smooth muscle cells (SMCs) from hPSCs have been described with considerably different SMC derivatives. In addition, we recently identified hPSC-derived pericytes, which are similar to their physiological counterparts, exhibiting unique features of blood vessel-residing perivascular cells, as well as multipotent mesenchymal precursors with therapeutic angiogenic potential. In this review we refer to methodologies for the development of a variety of perivascular cells from hPSCs with respect to developmental induction, differentiation capabilities, potency and their dual function as mesenchymal precursors. The therapeutic effect of hPSC-derived perivascular cells in experimental models of tissue engineering and regenerative medicine are described and compared to those of their native physiological counterparts.

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(1)105 the	(10)6 conventional	(19)3 group	(28)2 groups
(2)23 those	(11)5 controls,	(20)3 pure	(29)2 its
(3)19 control	(12)5 placebo	(21)2 TCDD	(30)2 long
(4)14 a	(13)5 untreated	(22)2 age-matched	(31)2 non-Hispanic
(5)12 that	(14)4 Exo(Normoxic)	(23)2 baseline	(32)2 non-transgenic
(6)10 controls	(15)4 all	(24)2 bur-prepared	(33)2 people
(7)10 other	(16)4 patients	(25)2 children	(34)2 plain
(8)9 healthy	(17)3 an	(26)2 controls),	(35)2 previous
(9)9 their	(18)3 drug	(27)2 experimental	(36)2 vehicle

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--- WordNet output for compared --- =>前年同期比で(は) Overview of verb compare The verb compare has 4 senses (first 3 from tagged texts) 1. (57) compare -- (examine and note the similarities or differences of; "John compared his haircut to his friend's"; "We compared notes after we had both seen the movie") 2. (12) compare -- (be comparable; "This car does not compare with our line of Mercedes") 3. (9) compare, liken, equate -- (consider or describe as similar, equal, or analogous; "We can compare the Han dynasty to the Romans"; "You cannot equate success in financial matters with greed") 4. compare -- (to form the comparative or superlative form on an adjective or adverb) --- WordNet end ---