* Vinorelbine rescue therapy for dogs with primary urinary bladder carcinoma.
- The goal of this study was to evaluate the anti-tumour activity and toxicoses of vinorelbine as a palliative rescue therapy for dogs with primary urinary bladder carcinoma. Thirteen dogs refractory to prior chemotherapeutics and one dog naïve to chemotherapeutic treatment were enrolled. Vinorelbine (15 mg m(-2) IV) was administered intravenously along with concurrent oral anti-inflammatory drugs, if tolerated. A median of six doses of vinorelbine (range: 1-16) was administered. Two dogs (14%) had partial responses, and eight (57%) experienced stable disease. Subjective improvement in clinical signs was noted in 11 dogs (78%). Adverse events were mild and primarily haematological in nature. Median time to progression was 93 days (range: 20-239 days). Median survival time for all dogs was 187 days; median survival for 13 pre-treated dogs was 207 days. Vinorelbine may have utility in the management of canine primary urinary bladder carcinoma and should be evaluated in a prospective study.
=>客観的な態度の, 臨床の, 臨床治療の, 臨床, 分析的な, 冷静な, 客観的な, 病院に関するものだ,
病院関係の
Overview of adj clinical
The adj clinical has 2 senses (first 2 from tagged texts)
1. (14) clinical -- (relating to a clinic or conducted in or as if in a clinic and depending on
direct observation of patients; "clinical observation"; "clinical case study")
2. (1) clinical -- (scientifically detached; unemotional; "he spoke in the clipped clinical
monotones typical of police testimony")
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