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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for changes out of >500 occurrences
332920 occurrences (No.57 in the rank) during 5 years in the PubMed. [no cache] 500 found
19) These findings revealed that chronic cannabis use may alter specific regional CB1 receptor expression through neuroadaptive changes in CB1 receptor availability, opening the way for the examination of specific CB1 -cannabis addiction interactions which may predict future cannabis-related treatment outcome.
--- ABSTRACT ---
PMID:24373053 DOI:10.1111/adb.12116
2015 Addiction biology
* [18F]MK-9470 PET measurement of cannabinoid CB1 receptor availability in chronic cannabis users.
- Δ(9) -Tetrahydrocannabinol, the main psychoactive component of cannabis, exerts its central effects through activation of the cerebral type 1 cannabinoid (CB1 ) receptor. Pre-clinical studies have provided evidence that chronic cannabis exposure is linked to decreased CB1 receptor expression and this is thought to be a component underlying drug tolerance and dependence. In this study, we make first use of the selective high-affinity positron emission tomography (PET) ligand [(18) F]MK-9470 to obtain in vivo measurements of cerebral CB1 receptor availability in 10 chronic cannabis users (age = 26.0 ± 4.1 years). Each patient underwent [(18) F]MK-9470 PET within the first week following the last cannabis consumption. A population of 10 age-matched healthy subjects (age = 23.0 ± 2.9 years) was used as control group. Parametric modified standardized uptake value images, reflecting CB1 receptor availability, were calculated. Statistical parametric mapping and volume-of-interest (VOI) analyses of CB1 receptor availability were performed. Compared with controls, cannabis users showed a global decrease in CB1 receptor availability (-11.7 percent). VOI-based analysis demonstrated that the CB1 receptor decrease was significant in the temporal lobe (-12.7 percent), anterior (-12.6 percent) and posterior cingulate cortex (-13.5 percent) and nucleus accumbens (-11.2 percent). Voxel-based analysis confirmed this decrease and regional pattern in CB1 receptor availability in cannabis users. These findings revealed that chronic cannabis use may alter specific regional CB1 receptor expression through neuroadaptive changes in CB1 receptor availability, opening the way for the examination of specific CB1 -cannabis addiction interactions which may predict future cannabis-related treatment outcome.
--- ABSTRACT END ---
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(4)26 were (11)5 at (18)3 was (25)2 related
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(6)13 and (13)3 as (20)2 can (27)2 such
(7)8 are (14)3 by (21)2 could (28)2 which

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--- WordNet output for changes --- Overview of noun change The noun change has 10 senses (first 7 from tagged texts) 1. (46) change, alteration, modification -- (an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago") 2. (45) change -- (a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage") 3. (17) change -- (the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election") 4. (13) change -- (the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains") 5. (2) change -- (the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change") 6. (1) change -- (a thing that is different; "he inspected several changes before selecting one") 7. (1) change -- (a different or fresh set of clothes; "she brought a change in her overnight bag") 8. change -- (coins of small denomination regarded collectively; "he had a pocketful of change") 9. change -- (money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver") 10. variety, change -- (a difference that is usually pleasant; "he goes to France for variety"; "it is a refreshing change to meet a woman mechanic") Overview of verb change The verb change has 10 senses (first 8 from tagged texts) 1. (57) change, alter, modify -- (cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue") 2. (54) change -- (undergo a change; become different in essence; losing one's or its original nature; "She changed completely as she grew older"; "The weather changed last night") 3. (13) change, alter, vary -- (become different in some particular way, without permanently losing one's or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarket's selection of vegetables varies according to the season") 4. (7) switch, shift, change -- (lay aside, abandon, or leave for another; "switch to a different brand of beer"; "She switched psychiatrists"; "The car changed lanes") 5. (6) change -- (change clothes; put on different clothes; "Change before you go to the opera") 6. (5) change, exchange, commute, convert -- (exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares") 7. (3) exchange, change, interchange -- (give to, and receive from, one another; "Would you change places with me?"; "We have been exchanging letters for a year") 8. (3) transfer, change -- (change from one vehicle or transportation line to another; "She changed in Chicago on her way to the East coast") 9. deepen, change -- (become deeper in tone; "His voice began to change when he was 12 years old"; "Her voice deepened when she whispered the password") 10. change -- (remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens") --- WordNet end ---