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return kwic search for cells out of >500 occurrences
856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [cache]

231) Oversecretion of MUC1 provide cancer cells with invasiveness, metastasis, and resistance to death induced by reactive oxygen species.

--- ABSTRACT ---

PMID:23608828 DOI:10.1097/COC.0b013e31828f5a07

2015 American journal of clinical oncology

* MUC1 as a potential target in anticancer therapies.

- MUC1 is a glycoprotein that is overexpressed in tumor cells. In normal cells it forms a protective layer against microbes and toxic chemicals, besides providing lubrication on ductal surfaces. Oversecretion of MUC1 provide cancer cells with invasiveness, metastasis, and resistance to death induced by reactive oxygen species. MUC1 is made up of 2 heterodimers, MUC1-N and MUC1-C. MUC1-N is heavily glycosylated at 5 regions of the variable N-tandem repeats. MUC1-C is divisible into extracellular, intracellular, and cytoplasmic domain (MUC1-C/CD). The extracellular domain serves as a docking site for epidermal growth factor receptors and other receptor kinases; the transmembrane domain serves to relay messages from extracellular to MUC1-C/CD. The MUC1-C/CD has 5 phosphorylating sites that on interacting with the SH2 domain of specific proteins can stimulate tumor growth. Therapies targeting MUC1 consists of monoclonal antibodies (MAb), vaccines, or small molecules (aptamers). MAb therapies are mainly aimed at MUC1-N with little success, however, new generation of MAb are being developed for MUC1-C. Vaccines (peptide, carbohydrate, glycopeptide, DNA, and dendritic cell) have been developed that recognizes the aberrant glycosylated region of the variable N-tandem repeats in MUC1-N, whereas new generation vaccines are aimed at the cytoplasmic region of MUC1-C. Aptamers (peptides that resemble DNA, RNA) have been used for blocking the dimerization of CQC region and the 5 phosphorylating region of MUC1-C. In addition, aptamers have been used as cytotoxic drug carriers. However, none of the therapies for MUC1 are currently in clinical application, as they need further refinement and evaluation.

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[frequency of next (right) word to cells]

(1)80 null	(15)5 as	(29)3 exposed	(43)2 expanded
(2)47 and	(16)5 expressed	(30)3 have	(44)2 expressing
(3)39 were	(17)5 of	(31)3 isolated	(45)2 had
(4)26 in	(18)5 which	(32)3 showed	(46)2 labeled
(5)12 (MSCs)	(19)4 (ASCs)	(33)3 we	(47)2 may
(6)11 was	(20)4 has	(34)2 (ASCs),	(48)2 play
(7)10 to	(21)4 is	(35)2 (BMSCs)	(49)2 present
(8)9 with	(22)4 on	(36)2 (ECFCs)	(50)2 remains
(9)7 are	(23)4 seeded	(37)2 (HSCs)	(51)2 such
(10)6 can	(24)4 within	(38)2 after	(52)2 the
(11)6 for	(25)3 (ASC)	(39)2 by	(53)2 via
(12)6 from	(26)3 (ECs)	(40)2 caused
(13)6 or	(27)3 (HUVECs)	(41)2 cultured
(14)6 that	(28)3 (hMSCs)	(42)2 derived

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---