ELIZA

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856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [no cache] 500 found

347) We developed an in vivo vascularization model in which human endothelial colony-forming cells (ECFCs) and human mesenchymal progenitor cells (MPCs) form blood vessel networks when co-injected (ECFC + MPC) into nude mice in rat tail type I collagen, bovine fibrin or synthetic peptide PuraMatrix matrices.

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PMID:23955835 DOI:10.1002/term.1803

2015 Journal of tissue engineering and regenerative medicine

* Rapid onset of perfused blood vessels after implantation of ECFCs and MPCs in collagen, PuraMatrix and fibrin provisional matrices.

- We developed an in vivo vascularization model in which human endothelial colony-forming cells (ECFCs) and human mesenchymal progenitor cells (MPCs) form blood vessel networks when co-injected (ECFC + MPC) into nude mice in rat tail type I collagen, bovine fibrin or synthetic peptide PuraMatrix matrices. We used three approaches to determine the onset of functional vascularization when ECFC + MPC suspended in these matrices were implanted in vivo. The first was immunohistochemistry to detect vessels lined by human endothelial cells and filled with red blood cells. The second was in vivo vascular staining by tail vein injection of a mixture of Ulex europaeus agglutinin I (UEA-I), a lectin specific for human endothelium, and Griffonia simplicifolia isolectin B4 (GS-IB4 ), a lectin specific for rodent endothelium. The third approach employed contrast-enhanced ultrasound to measure the perfusion volumes of implants in individual animals over time. Human endothelial-lined tubular structures were detected in vivo on days 1 and 2 after implantation, with perfused human vessels detected on days 3 and 4. Contrast-enhanced ultrasound revealed significant perfusion of ECFC + MPC/collagen implants on days 1-4, at up to 14% perfused vascular volume. ECFC + MPC implanted in fibrin and PuraMatrix matrices also supported perfusion at day 1, as assessed by ultrasound (at 12% and 23% perfused vascular volume, respectively). This model demonstrates that ECFC + MPC suspended in any of the three matrices initiated a rapid onset of vascularization. We propose that ECFC + MPC delivered in vivo provide a means to achieve rapid perfusion of tissue-engineered organs or for in situ tissue repair.

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(1)80 null	(15)5 as	(29)3 exposed	(43)2 expanded
(2)47 and	(16)5 expressed	(30)3 have	(44)2 expressing
(3)39 were	(17)5 of	(31)3 isolated	(45)2 had
(4)26 in	(18)5 which	(32)3 showed	(46)2 labeled
(5)12 (MSCs)	(19)4 (ASCs)	(33)3 we	(47)2 may
(6)11 was	(20)4 has	(34)2 (ASCs),	(48)2 play
(7)10 to	(21)4 is	(35)2 (BMSCs)	(49)2 present
(8)9 with	(22)4 on	(36)2 (ECFCs)	(50)2 remains
(9)7 are	(23)4 seeded	(37)2 (HSCs)	(51)2 such
(10)6 can	(24)4 within	(38)2 after	(52)2 the
(11)6 for	(25)3 (ASC)	(39)2 by	(53)2 via
(12)6 from	(26)3 (ECs)	(40)2 caused
(13)6 or	(27)3 (HUVECs)	(41)2 cultured
(14)6 that	(28)3 (hMSCs)	(42)2 derived

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---