ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cells out of >500 occurrences
856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [no cache] 500 found
22) E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent interactions between adjacent epithelial cells.
--- ABSTRACT ---
PMID:23572389 DOI:10.1177/0748233713484657
2015 Toxicology and industrial health
* Hypermethylation of P15, P16, and E-cadherin genes in ovarian cancer.
- Both p16 and p15 proteins are inhibitors of cyclin-dependent kinases that prevent the cell going through the G1/S phase transaction. E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent interactions between adjacent epithelial cells. Two groups of patients were selected: the first group suffered from epithelial serous ovarian tumors and the second group suffered from benign ovarian lesions; ovarian tissue samples from all the subjects (benign and malignant) were subjected to methylation-specific polymerase chain reaction for methylated and unmethylated alleles of the genes (E-cadherin, p15, and p16). Results obtained showed that aberrant methylation of p15 and p16 genes were detected in 64.29 and 50% of ovarian cancer patients, while E-cadherin hypermethylation was detected in 78.57% of ovarian cancer patients. Methylation of E-cadherin was significantly correlated with different stage of disease (p < 0.05). It was found that the risk of E-cadherin hypermethylation was 1.347-fold, while risk of p15 hypermethylation was 1.543-fold and p16 was 1.2-fold among patients with ovarian cancer than that among patients with benign ovarian lesions. In conclusion, Dysfunction of the cell cycle and/or the cell-cell adhesion molecule plays a role in the pathogenesis of ovarian cancer and that the analysis of the methylation of p15 and E-cadherin genes can provide clinically important evidence on which to base the treatment.
--- ABSTRACT END ---
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(1)80 *null* (15)5 as (29)3 exposed (43)2 expanded
(2)47 and (16)5 expressed (30)3 have (44)2 expressing
(3)39 were (17)5 of (31)3 isolated (45)2 had
(4)26 in (18)5 which (32)3 showed (46)2 labeled
(5)12 (MSCs) (19)4 (ASCs) (33)3 we (47)2 may
(6)11 was (20)4 has (34)2 (ASCs), (48)2 play
(7)10 to (21)4 is (35)2 (BMSCs) (49)2 present
(8)9 with (22)4 on (36)2 (ECFCs) (50)2 remains
(9)7 are (23)4 seeded (37)2 (HSCs) (51)2 such
(10)6 can (24)4 within (38)2 after (52)2 the
(11)6 for (25)3 (ASC) (39)2 by (53)2 via
(12)6 from (26)3 (ECs) (40)2 caused
(13)6 or (27)3 (HUVECs) (41)2 cultured
(14)6 that (28)3 (hMSCs) (42)2 derived

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---