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379) Genome characterization efforts have identified genetic alterations in multiple components of the NF-κB pathway, some of which have been shown to be essential for cancer initiation and tumor maintenance.
* TRAF2 is an NF-κB-activating oncogene in epithelial cancers.
- Aberrant nuclear factor (NF)-κB activation is frequently observed in human cancers. Genome characterization efforts have identified genetic alterations in multiple components of the NF-κB pathway, some of which have been shown to be essential for cancer initiation and tumor maintenance. Here, using patient tumors and cancer cell lines, we identify the NF-κB regulator, TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2), as an oncogene that is recurrently amplified and rearranged in 15% of human epithelial cancers. Suppression of TRAF2 in cancer cells harboring TRAF2 copy number gain inhibits proliferation, NF-κB activation, anchorage-independent growth and tumorigenesis. Cancer cells that are dependent on TRAF2 also require NF-κB for survival. The phosphorylation of TRAF2 at serine 11 is essential for the survival of cancer cells harboring TRAF2 amplification. Together, these observations identify TRAF2 as a frequently amplified oncogene.
=>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌
Overview of noun cancer
The noun cancer has 5 senses (first 1 from tagged texts)
1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal
and uncontrolled cell division; it may spread to other parts of the body through the lymphatic
system or the blood stream)
2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer)
3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini)
4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from
about June 21 to July 22)
5. Cancer, genus Cancer -- (type genus of the family Cancridae)
--- WordNet end ---