ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cancer out of >500 occurrences
505522 occurrences (No.25 in the rank) during 5 years in the PubMed. [no cache] 500 found
18) Importantly, significant correlation between levels of AKIP1 and VEGF-C is observed in a cohort of human ESCC, as well as in non-small cell lung cancer, hepatocellular carcinoma and ovarian cancer.
--- ABSTRACT ---
PMID:24413079 DOI:10.1038/onc.2013.559
2015 Oncogene
* Overexpression of AKIP1 promotes angiogenesis and lymphangiogenesis in human esophageal squamous cell carcinoma.
- A-kinase-interacting protein 1 (AKIP1) is found to be overexpressed in breast and prostate cancers, suggesting that AKIP1 might act as a potent oncogenic protein. However, the clinical significance and biological role of AKIP1 in cancer progression remain largely unknown. Herein, we report that AKIP1 is markedly overexpressed in esophageal squamous cell carcinoma (ESCC) cell lines and clinical ESCC samples. AKIP1 expression significantly correlates with ESCC progression and patients' shorter survival time. Furthermore, we find that overexpressing AKIP1 induces, whereas silencing AKIP1 reduces, ESCC angiogenesis and lymphangiogenesis both in vitro and in vivo. Moreover, we demonstrate that AKIP1 transcriptionally upregulates vascular endothelial growth factor-C (VEGF-C) via interaction with its promoter through cooperation with multiple transcriptional factors, including SP1, AP2 and nuclear factor-κB (NF-κB). Importantly, significant correlation between levels of AKIP1 and VEGF-C is observed in a cohort of human ESCC, as well as in non-small cell lung cancer, hepatocellular carcinoma and ovarian cancer. Hence, these findings indicate an important role for AKIP1 in ESCC angiogenesis and lymphangiogenesis, and uncover a novel mechanism for the upregulation of VEGF-C in cancers.
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[frequency of next (right) word to cancer]
(1)65 *null* (14)6 therapy (27)3 of (40)2 epigenetics
(2)48 cells (15)6 tissues (28)3 patients, (41)2 growth
(3)33 and (16)5 cells, (29)3 research (42)2 initiation
(4)32 cell (17)5 progression (30)3 was (43)2 prevention
(5)23 patients (18)5 registries (31)2 (GC) (44)2 registry
(6)15 in (19)4 at (32)2 biology (45)2 study
(7)14 is (20)4 deaths (33)2 but (46)2 susceptibility
(8)12 risk (21)4 has (34)2 can (47)2 than
(9)12 screening (22)4 mortality (35)2 care (48)2 treated
(10)12 stem (23)3 (CRC) (36)2 development (49)2 treatment
(11)9 survivors (24)3 as (37)2 diagnostic (50)2 using
(12)7 with (25)3 cases (38)2 drug
(13)6 are (26)3 metabolism (39)2 drugs

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--- WordNet output for cancer --- =>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌 Overview of noun cancer The noun cancer has 5 senses (first 1 from tagged texts) 1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream) 2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer) 3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini) 4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22) 5. Cancer, genus Cancer -- (type genus of the family Cancridae) --- WordNet end ---