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346933 occurrences (No.53 in the rank) during 5 years in the PubMed. [no cache] 500 found
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346933 occurrences (No.53 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 209) Concerning colloidal stability, protein solutions of different kD values are evaluated, based on their initial solution opalescence, to assess protein association. |
| PMID:24392929 DOI:10.3109/10837450.2013.871032 |
| 2015 Pharmaceutical development and technology |
| * Prediction of colloidal stability of high concentration protein formulations. |
| - A major aspect determining the colloidal properties of proteins in solution is the interaction between them and with surrounding molecules. These interactions can be described by the concentration dependency of the protein diffusivity (kD), as derived by dynamic light scattering and was determined for different solutions of monoclonal antibodies varying in pH, ionic strength and presence/absence of co-solute(s). Concerning colloidal stability, protein solutions of different kD values are evaluated, based on their initial solution opalescence, to assess protein association. The current investigation shows that solution conditions with large kD values, indicating high repulsive protein-protein interactions, show lower initial opalescence, compared to solution conditions with low kD values. Upon applying stirring stress, to assess colloidal stability, the trend is such that, the higher kD values are, the more stable the protein solutions are, as long as the thermodynamic and conformational stability is not impaired. Besides, kD allows ranking of solution conditions for highly concentrated immunoglobulin solutions up to concentrations of ∼200 mg mL(-1) with regard to protein self-association and thus opalescent properties. The present study shows that the protein interaction parameter kD can be used as a surrogate parameter for a qualitative prediction of protein association and, thus, colloidal protein stability. |
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