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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

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346933 occurrences (No.53 in the rank) during 5 years in the PubMed. [no cache] 500 found
196) Nowadays, more than 20% of all fundamental translational research studies regarding EAC are partially or entirely based on these cell lines.
--- ABSTRACT ---
PMID:23795680 DOI:10.1111/dote.12095
2015 Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
* Translational research on esophageal adenocarcinoma: from cell line to clinic.
- Human esophageal adenocarcinoma (EAC) cell lines have made a substantial contribution to elucidating mechanisms of carcinogenesis and drug discovery. Model research on EAC relies almost entirely on a relatively small set of established tumor cell lines because appropriate animal models are lacking. Nowadays, more than 20% of all fundamental translational research studies regarding EAC are partially or entirely based on these cell lines. The ready availability of these cell lines to investigators worldwide have resulted in more than 250 publications, including many examples of important biomedical discoveries. The high genomic similarities (but certainly not completely identical) between the EAC cell lines and their original tumors provide rational for their use. Recently, in a collaborative effort all available EAC cell lines have been verified resulting in the establishment of a reliable panel of 10 EAC cell lines. It could be expected that the value of these cell lines increases as unlimited source of tumor material because new biomedical techniques require more tumor cells and the supply of viable tumor cells is diminishing because of neoadjuvant chemo(radio)therapy of patients with EAC. Here, we review the history of the EAC cell lines and their utility in translational research and biomedical discovery.
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(1)142 the (8)4 data (15)2 clinical (22)2 partial
(2)40 a (9)4 our (16)2 combined (23)2 previous
(3)19 these (10)4 two (17)2 current (24)2 radiological
(4)9 their (11)3 16S (18)2 functional (25)2 sequences
(5)7 this (12)3 an (19)2 histological (26)2 shear
(6)5 its (13)2 all (20)2 interviews (27)2 small
(7)4 both (14)2 changes (21)2 morphology (28)2 surveys

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--- WordNet output for based --- =>に基づき Overview of verb base The verb base has 3 senses (first 1 from tagged texts) 1. (75) establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") 2. base -- (situate as a center of operations; "we will base this project in the new lab") 3. free-base, base -- (use (purified cocaine) by burning it and inhaling the fumes) Overview of adj based The adj based has 2 senses (first 2 from tagged texts) 1. (3) based -- (having a base; "firmly based ice") 2. (1) based -- (having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes") --- WordNet end ---