ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for based on out of >500 occurrences
346933 occurrences (No.53 in the rank) during 5 years in the PubMed. [no cache] 500 found
153) An example based on a clinical trial from a development programme for a vaccine against human papillomavirus (HPV) will be presented.
--- ABSTRACT ---
PMID:21865269 DOI:10.1177/0962280211416299
2015 Statistical methods in medical research
* Using proportion of similar response to evaluate correlates of protection for vaccine efficacy.
- A question of interest in many vaccine clinical development programmes is whether vaccine-induced serum antibody level can be used as a correlate of vaccine efficacy; that is, whether serum antibody levels induced by a candidate vaccine can reliably predict the risk of breakthrough disease. Traditionally, analyses to answer this question have been based on modelling the incidence of breakthrough disease as a function of antibody level, among vaccinated subjects in clinical trials. The Proportion of Similar Response (PSR) method will be described and explored, and compared to the Receive Operator Characteristics (ROC) curve as a graphical tool and the area under the ROC (AUROC) as a summary measure in the context of evaluating correlates of protection. A way to use PSR analysis as complementary to Youden's index as a simple and elegant method to determine the discriminatory ability of a test and to set an optimal threshold value will be presented. In addition, the relationships among PSR and other measures of overlap and discrimination will be described. An example based on a clinical trial from a development programme for a vaccine against human papillomavirus (HPV) will be presented.
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(1)142 the (8)4 data (15)2 clinical (22)2 partial
(2)40 a (9)4 our (16)2 combined (23)2 previous
(3)19 these (10)4 two (17)2 current (24)2 radiological
(4)9 their (11)3 16S (18)2 functional (25)2 sequences
(5)7 this (12)3 an (19)2 histological (26)2 shear
(6)5 its (13)2 all (20)2 interviews (27)2 small
(7)4 both (14)2 changes (21)2 morphology (28)2 surveys

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--- WordNet output for based --- =>に基づき Overview of verb base The verb base has 3 senses (first 1 from tagged texts) 1. (75) establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") 2. base -- (situate as a center of operations; "we will base this project in the new lab") 3. free-base, base -- (use (purified cocaine) by burning it and inhaling the fumes) Overview of adj based The adj based has 2 senses (first 2 from tagged texts) 1. (3) based -- (having a base; "firmly based ice") 2. (1) based -- (having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes") --- WordNet end ---