ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for based out of >500 occurrences
404793 occurrences (No.42 in the rank) during 5 years in the PubMed. [cache]
32) Based on these observations, we propose that bufalin is acts as an antiinvasive agent by inhibiting MMP-2 and -9 and involving PI3K/AKT and NF-κB pathways.
--- ABSTRACT ---
PMID:23949904 DOI:10.1002/tox.21896
2015 Environmental toxicology
* Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.
- Metastasis plays an important role in mortality of cancer patients. Migration and invasion are the major characteristics of tumor metastasis. The induction of matrix metalloproteinases (MMPs) such as MMP-2 and -9 are particularly important for the invasiveness of various cancer cells. Bufalin, a class of toxic steroids, was purified from the skin glands of Bufo gargarizans or Bufo melanostictus; it is known to inhibit proliferation of human cancer cells. In this study, we investigated the antiinvasive mechanisms of bufalin in the human hepatocellular cancer cell line SK-Hep1. Bufalin significantly reduced serum-induced cell invasion and migration. Furthermore, bufalin markedly inhibited MMP-2 and -9 activity, mRNA expression and protein levels in SK-Hep1 cells. Bufalin attenuated phosphoinisitide-3-kinase (PI3K) and phosphorylation of AKT which was associated with reduced levels of nuclear factor kappa B (NF-κB). Bufalin also suppressed protein levels of FAK and Rho A, VEGF, MEKK3, MKK7, and uPA and it diminished NF-κB translocation. Based on these observations, we propose that bufalin is acts as an antiinvasive agent by inhibiting MMP-2 and -9 and involving PI3K/AKT and NF-κB pathways. Bufalin is a potential therapeutic agent that may have efficacy in preventing the invasion and metastasis of malignant liver tumors.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to based]
(1)247 on (10)3 approach (19)2 chemotherapy (28)2 physical
(2)10 method (11)3 hydrogels (20)2 computer-tailored (29)2 rehabilitation
(3)10 therapies (12)3 information (21)2 financing (30)2 retrospective
(4)5 cross-sectional (13)3 study (22)2 learning (31)2 scaffolds
(5)5 upon (14)3 techniques (23)2 methods (32)2 strategy
(6)4 survey (15)3 therapeutic (24)2 modelling (33)2 studies
(7)4 tissue (16)2 NPWT (25)2 morphometry (34)2 telephone
(8)3 CRT (17)2 RUTF (26)2 nutrient (35)2 vaccination
(9)3 anti-bullying (18)2 and (27)2 palliative

add keyword

--- WordNet output for based --- =>に基づき Overview of verb base The verb base has 3 senses (first 1 from tagged texts) 1. (75) establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") 2. base -- (situate as a center of operations; "we will base this project in the new lab") 3. free-base, base -- (use (purified cocaine) by burning it and inhaling the fumes) Overview of adj based The adj based has 2 senses (first 2 from tagged texts) 1. (3) based -- (having a base; "firmly based ice") 2. (1) based -- (having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes") --- WordNet end ---