ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for based out of >500 occurrences
404793 occurrences (No.42 in the rank) during 5 years in the PubMed. [no cache] 500 found
263) The specific targeting of cells to sites of tissue damage in vivo is a major challenge precluding the success of stem cell-based therapies.
--- ABSTRACT ---
PMID:23281176 DOI:10.1002/term.1636
2015 Journal of tissue engineering and regenerative medicine
* An in vitro model of mesenchymal stem cell targeting using magnetic particle labelling.
- The specific targeting of cells to sites of tissue damage in vivo is a major challenge precluding the success of stem cell-based therapies. Magnetic particle-based targeting may provide a solution. Our aim was to provide a model system to study the trapping and potential targeting of human mesenchymal stem cells (MSCs) during in vitro fluid flow, which ultimately will inform cell targeting in vivo. In this system magnet arrays were used to trap superparamagnetic iron oxide particle-doped MSCs. The in vitro experiments demonstrated successful cell trapping, where the volume of cells trapped increased with magnetic particle concentration and decreased with increasing flow rate. Analysis of gene expression revealed significant increases in COL1A2 and SOX9. Using principles established in vitro, a proof-of-concept in vivo experiment demonstrated that magnetic particle-doped, luciferase-expressing MSCs were trapped by an implanted magnet in a subcutaneous wound model in nude mice. Our results demonstrate the effectiveness of using an in vitro model for testing superparamagnetic iron oxide particles to develop successful MSC targeting strategies during fluid flow, which ultimately can be translated to in vivo targeted delivery of cells via the circulation in a variety of tissue-repair models.
--- ABSTRACT END ---
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[frequency of next (right) word to based]
(1)247 on (10)3 approach (19)2 chemotherapy (28)2 physical
(2)10 method (11)3 hydrogels (20)2 computer-tailored (29)2 rehabilitation
(3)10 therapies (12)3 information (21)2 financing (30)2 retrospective
(4)5 cross-sectional (13)3 study (22)2 learning (31)2 scaffolds
(5)5 upon (14)3 techniques (23)2 methods (32)2 strategy
(6)4 survey (15)3 therapeutic (24)2 modelling (33)2 studies
(7)4 tissue (16)2 NPWT (25)2 morphometry (34)2 telephone
(8)3 CRT (17)2 RUTF (26)2 nutrient (35)2 vaccination
(9)3 anti-bullying (18)2 and (27)2 palliative

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--- WordNet output for based --- =>に基づき Overview of verb base The verb base has 3 senses (first 1 from tagged texts) 1. (75) establish, base, ground, found -- (use as a basis for; found on; "base a claim on some observation") 2. base -- (situate as a center of operations; "we will base this project in the new lab") 3. free-base, base -- (use (purified cocaine) by burning it and inhaling the fumes) Overview of adj based The adj based has 2 senses (first 2 from tagged texts) 1. (3) based -- (having a base; "firmly based ice") 2. (1) based -- (having a base of operations (often used as a combining form); "a locally based business"; "an Atlanta-based company"; "carrier-based planes") --- WordNet end ---