67) COMT genotype was not associated with a history of violent or non-violent crime. |
PMID:24118473 DOI:10.1111/adb.12098 |
2015 Addiction biology |
* Val158Met COMT polymorphism and risk of aggression in alcohol dependence. |
- Aggression, violence and antisocial behavior are common in alcoholism, but their biological basis is poorly understood. Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. We tested this hypothesis in a sample of treatment-seeking alcohol-dependent in-patients (293 German patients and 499 controls, and additional 190 Polish patients as replication sample). As expected, patients with a history of violent or non-violent crime were more often male, had an earlier onset of alcoholism and more withdrawal seizures and delirium tremens, and were more likely to have a history of suicide attempts. COMT genotype was not associated with a history of violent or non-violent crime. More studies are needed on the neurobiological basis of aggression and violence in alcoholism. |
(1)51 the | (16)4 significantly | (31)2 being | (46)2 less |
(2)31 a | (17)3 FIQ | (32)2 diabetes | (47)2 many |
(3)12 increased | (18)3 cancer | (33)2 different | (48)2 maternal |
(4)12 lower | (19)3 chronic | (34)2 early | (49)2 nephrolithiasis |
(5)9 higher | (20)3 more | (35)2 excessive | (50)2 normal |
(6)8 an | (21)3 other | (36)2 faster | (51)2 parenchymal |
(7)7 decreased | (22)3 perceived | (37)2 female | (52)2 physical |
(8)6 poor | (23)3 shorter | (38)2 gene | (53)2 positive |
(9)5 both | (24)3 smoking | (39)2 genetic | (54)2 reductions |
(10)5 greater | (25)3 specific | (40)2 good | (55)2 stress |
(11)4 adverse | (26)2 JS | (41)2 having | (56)2 them |
(12)4 negative | (27)2 SWD | (42)2 high | (57)2 this |
(13)4 poorer | (28)2 alterations | (43)2 implementation | (58)2 undernutrition |
(14)4 reduced | (29)2 altered | (44)2 improvements | (59)2 very |
(15)4 significant | (30)2 any | (45)2 internalizing |
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