53) This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes. |
PMID:23965335 DOI:10.1177/1076029613501542 |
2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
* Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia. |
- No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes. |
(1)51 the | (16)4 significantly | (31)2 being | (46)2 less |
(2)31 a | (17)3 FIQ | (32)2 diabetes | (47)2 many |
(3)12 increased | (18)3 cancer | (33)2 different | (48)2 maternal |
(4)12 lower | (19)3 chronic | (34)2 early | (49)2 nephrolithiasis |
(5)9 higher | (20)3 more | (35)2 excessive | (50)2 normal |
(6)8 an | (21)3 other | (36)2 faster | (51)2 parenchymal |
(7)7 decreased | (22)3 perceived | (37)2 female | (52)2 physical |
(8)6 poor | (23)3 shorter | (38)2 gene | (53)2 positive |
(9)5 both | (24)3 smoking | (39)2 genetic | (54)2 reductions |
(10)5 greater | (25)3 specific | (40)2 good | (55)2 stress |
(11)4 adverse | (26)2 JS | (41)2 having | (56)2 them |
(12)4 negative | (27)2 SWD | (42)2 high | (57)2 this |
(13)4 poorer | (28)2 alterations | (43)2 implementation | (58)2 undernutrition |
(14)4 reduced | (29)2 altered | (44)2 improvements | (59)2 very |
(15)4 significant | (30)2 any | (45)2 internalizing |
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