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579792 occurrences (No.16 in the rank) during 5 years in the PubMed. [no cache] 500 found
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579792 occurrences (No.16 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 28) Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. |
| PMID:23038715 DOI:10.1177/1533317512461557 |
| 2015 American journal of Alzheimer's disease and other dementias |
| * Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms. |
| - Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ∊3/∊3 and ∊3/∊4 genotype frequencies were significantly higher in control and case groups, respectively. While ∊3 allele frequencies were significantly higher in the control group, ∊2 and ∊4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ∊4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study. |
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